Hebei Provincial Center for Disease Control and Prevention

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...

HMGA1 accelerates vascular smooth muscle cell osteogenic phenotype transdifferentiation by elevating pro-inflammatory cytokine IL-1β transcription in chronic kidney disease

Abstract Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is recognized as a core pathological process underlying vascular calcification (VC). The inflammatory response contributes to the development of phenotypic switch, yet there is a lack of therapeutic strat...