Hebei North University

NCKAP1 Is Essential for SLC7A11-Dependent Disulfide Stress-Induced Cell Death Under Glucose Starvation in an Oral Squamous Cell Model

Background: Oral squamous cell carcinoma (OSCC) has a poor prognosis and requires new therapeutic strategies. Disulfidptosis is a recently defined form of cell death that occurs in SLC7A11-high cells under glucose starvation and has been linked to collapse of the actin cytoskelet...

Beyond ubiquitination the expanding regulatory network of TRIM proteins in endometrial disorders and cancer

Abstract Endometrial disorders comprise a biologically connected disease spectrum that extends from endometriosis (EMs) and endometrial hyperplasia (EH) to endometrial carcinoma (EC) and together they impose a considerable health burden on women worldwide. Although these conditio...

An exploratory study of safety and efficacy of camrelizumab plus induction chemotherapy followed by concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma

This study aims to prospectively evaluate the safety and efficacy of camrelizumab plus induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in locally advanced nasopharyngeal carcinoma (LA-NPC). This prospective study (ChiCTR2500102158) enrolled patients with hi...

Frailty and bone quality as the predictors of mechanical complications for patients after lumbar interbody fusion: a retrospective cohort study

Mechanical complications following lumbar interbody fusion are common in in elderly patients, particularly those with compromised bone quality. The MRI-based vertebral bone quality (VBQ) score assesses bone quality, while the modified frailty index (mFI) captures systemic physiol...

Pathogen detection and gut microbiota analysis in subcutaneous abscesses in goats

Subcutaneous abscesses in goats result in carcass condemnation, reduced milk and wool production, growth retardation, and increased mortality, thereby causing substantial economic losses in goat production systems. This study investigated the major pathogens associated with subcu...

Dynamic multi-priority admission scheduling for multimorbid patients: an MDP approach incorporating balking penalties

Efficient admission scheduling for multimorbid patients remains a critical challenge in hospital operations, particularly in mitigating patient balking behavior caused by bed shortages. This study investigates the multi-priority admission problem across Endocrinology (ED), Cardio...

Association of an exploratory triglyceride glucose–visceral lipoprotein composite with incident stroke in CKM-staged Chinese middle-aged and older adults: a prospective CHARLS study

Cardiovascular-kidney-metabolic (CKM) syndrome links adiposity, insulin resistance, kidney dysfunction, and vascular disease. Whether a composite combining the triglyceride-glucose index (TyG), visceral adiposity, and LDL-C burden is associated with incident stroke beyond simpler...

In situ precipitation of nanoscale α-Fe enables high-performance Nd2Fe14B/α-Fe nanocomposite ribbons

Nanocomposite magnets combining hard Nd2Fe14B and soft α-Fe phases are promising for surpassing the energy product limit of single-phase permanent magnets, but conventional routes using external Fe powders suffer from poor interfacial compatibility and uncontrolled soft-phase coa...

Evaluation of the efficacy and safety of first-line therapies for peripheral T-cell lymphoma: a systematic review and network meta-analysis

Objective To compare the efficacy and safety of first-line therapies for peripheral T-cell lymphoma (PTCL) via network meta-analysis. Methods We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) evaluating first-l...

Experimental study on the dynamic shear modulus of foam lightweight soil based on resonant column tests

Abstract To gain a deeper undestanding of the dynamic characteristics of foam lightweight soil (FLS) subgrades in cold regions, resonant column tests were conducted to investigate the effects of wet density, clay content, and freeze–thaw cycles on the dynamic properties of FLS. T...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...