Hebei General Hospital

Associations of Anatomical Location and Reader Experience With the Diagnostic Performance of Multiparametric MRI ‐Derived VI ‐ RADS for Muscle Invasive Bladder Cancer: A Multicenter Multireader Study

ABSTRACT Background The associations of tumor location and reader experience with Vesical Imaging‐Reporting and Data System (VI‐RADS) performance remain unclear. Purpose To evaluate the associations of tumor location and reader experience with VI‐RADS performance in detecting mus...

Protective Effects of Kaempferol on Ovarian Torsion/Detorsion-induced Oxidative Stress, Inflammation, and Apoptosis in Adult Female Rats

Background Ovarian torsion, a significant gynecological condition, encompasses the entire or partial twisting of the ovary around its suspensory ligaments, consequently impairing its blood supply and causing ischemic injury to the ovary. This ischemic episode can result in signif...

Diagnostic accuracy and prognostic value of lncRNA H19 in gastric cancer: a systematic review and meta-analysis

Abstract Background LncRNA H19 is upregulated considerably in gastric cancer and participates in its apoptosis, proliferation, migration, invasion, and metastasis. The objective of this meta-analysis is to demonstrate its diagnostic and prognostic values for gastric cancer. Metho...

Exosomes From Cancer‐Associated Fibroblasts Suppress Ferroptosis and CD8 + T Cell Effector Function in Gastric Cancer via miR ‐4435/ NDUFA10 Axis

ABSTRACT Cancer‐associated fibroblasts (CAFs) are pivotal stromal component in tumor microenvironment (TME) and participate in regulating tumor development and progression via exosomes (exos) mediated intercommunication. However, the intricate mechanism underlying the exosomal mi...

Multi-omics and spatial transcriptomics reveal that S100A10 drives CD8+ T-cell exhaustion and immune evasion in hepatocellular carcinoma through cPLA2-5-LOX-mediated arachidonic acid metabolism and ferroptosis

Immune evasion in hepatocellular carcinoma (HCC) represents a major biological barrier limiting the efficacy of immunotherapy, yet its molecular basis remains incompletely understood. Increasing evidence indicates that tumor metabolic reprogramming and ferroptosis-related signali...

CSTF2 facilitates ATAD2 translation via m⁶A recognition to drive ER-positive breast cancer metabolic reprogramming and tumor progression

Abstract Objective Breast cancer (BC) is the most common malignancy among women worldwide, accounting for 11.7% of female cancer cases. Cleavage stimulation factor subunit 2 ( CSTF2 ), a key RNA-binding protein, modulates tumor development by influencing N⁶-methyladenosine (m⁶A)...

Molecular and clinical characterization of human adenovirus in hospitalized pediatric respiratory infections: a five-year study

Abstract Background Human adenovirus (HAdV) is a major pathogen of responsible for respiratory tract infections (RTIs) in children in China. This study analyzed clinical data from hospitalized pediatric HAdV infections over a five-year period to characterize the epidemiology, cli...

Fibroblast Growth Factor 21 and Its Relationship with Central Precocious Puberty in Girls

Abstract Background Studies have found that obesity and insulin resistance are linked to central precocious puberty (CPP) in girls, while serum fibroblast growth factor 21 (FGF21) levels are associated with obesity and insulin resistance and related to ovarian development, reprod...

Dynamic evolution of chaperone-mediated autophagy is associated with tumor microenvironment remodeling and prognostic stratification in lung adenocarcinoma: insights from single-cell transcriptomics, ensemble machine learning, and experimental validation

BACKGROUND: Lung adenocarcinoma (LUAD) shows prognostic heterogeneity, and tumor-node-metastasis (TNM) staging is limited for individualized management. Chaperone-mediated autophagy (CMA) maintains proteostasis, but its role during adenocarcinoma in situ (AIS)-minimally invasive...