Heart and Diabetes Center North Rhine-Westphalia

Clinical Decision-Making in High-Risk Cross-Platform Redo-TAVI: Pre-Emptive Coronary Wiring and Chimney Stenting

Background: Redo transcatheter aortic valve implantation (TAVI) in patients with prior transapical SAPIEN 3 valves carries a significant risk of coronary obstruction. Chimney stenting is an established strategy to maintain coronary perfusion in high-risk valve-in-valve (ViV) proc...

Hepatitis E virus genome plasticity: a marker of chronicity and therapy failure?

Abstract Hepatitis E virus (HEV) is a globally distributed zoonotic pathogen, spread by contaminated food and blood products, and a leading cause of acute viral hepatitis. Recent data indicate that the HEV genome contains a highly heterogeneous hypervariable region (HVR) that can...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...