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Targeting Metallo-β-Lactamases:Discovery ofNovel Dihydro-Chromeno Pyrrole (dCPs) Derivatives for Combating Drug-ResistantInfections

Abstract Clinically approved therapies have established that combining β-lactam antibiotics with β-lactamase inhibitors is an effective strategy to counter antibiotic resistance; however, infections caused by metallo-β-lactamase (MBL) producing bacteria remain a critical unmet me...

Effectiveness of RSV Prevention Strategies in US Infants: 2024–2025

OBJECTIVE: In 2023, 2 products, a long-acting monoclonal antibody (nirsevimab) and maternal respiratory syncytial virus (RSV) vaccination, were recommended in the United States to prevent severe RSV disease among infants in their first RSV season. Low uptake during the 2023 to 20...