Health Sciences North

High-Dose Gestational Irradiation Disrupts Fetal Mouse Brain Structure and Region-Specific Transcriptomic Profiles

Background/Objectives: Prenatal exposure to ionizing radiation can disrupt neurodevelopment, yet the region-specific structural and molecular responses of the developing brain remain incompletely understood. In particular, how gestational irradiation alters transcriptional progra...

Circulating Tumor DNA (ctDNA) for Minimal Residual Disease (MRD) Detection in Colorectal Cancer (CRC): Current Evidence, Clinical Applications, and Future Directions

Minimal residual disease (MRD) is a major contributor to colorectal cancer (CRC) recurrence following curative-intent treatment, yet conventional surveillance methods may fail to detect residual disease at its earliest stages. Circulating tumor DNA (ctDNA) has emerged as a minima...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Exploring medical interns’ perceptions and satisfaction with task-based microlearning in an otolaryngology rotation: a mixed-methods study

Abstract Background The integration of traditional and modern educational approaches in contemporary curricula, particularly in medical education, is becoming increasingly necessary. Medical schools and healthcare institutions are seeking to enhance the effectiveness and efficien...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

Role of consolidative surgery after chemotherapy in recurrent/metastatic adrenal cortical cancer (ACC): Princess Margaret Cancer Centre experience

Recurrent/Metastatic (R/M) ACC is aggressive with few effective treatment options. The role of surgery after chemotherapy remains unclear. Moreover, prognostic factors in R/M ACC are not well defined. R/M ACC patients treated at Princess Margaret Cancer Centre (2002–2019) were re...