Health Sciences Centre

Blood proteomics of menopause map to brain aging and dementia risk

Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...

Relational Accountability as a Conflict Resolution Framework for Rebuilding Trust in Indigenous Research Partnerships

Conflict is an inevitable part of research, even when research emphasizes collaboration, reciprocity, participatory, and a community-based approach. For community-based Indigenous research, this is compounded with the enduring influence of colonial research paradigms and historic...

Readability and Quality of Online Patient Education Materials: Thyroid Radiofrequency Ablation

OBJECTIVE: To assess the readability and quality of online patient education materials regarding thyroid radiofrequency ablation. METHODS: Google searches were conducted using six search terms related to thyroid radiofrequency ablation, and the top 50 webpages from each search we...

Ebola Virus RNA Persists in Reproductive Tissues and Sperm of Male Ifnar1−/− Mice After Resolution of Viremia

Ebola virus (EBOV) has been shown to persist in the reproductive tracts of male Ebola virus disease (EVD) survivors ranging from months to years following recovery, with shedding of EBOV in semen leading to chains of disease transmission. In the current study, we used a mouse mod...

Assessing Challenges and Barriers to Effective Wound Care in Rural Indigenous Communities

OBJECTIVE: To explore the lived experiences of patients with chronic wounds from a remote Indigenous community in Northern Manitoba, Canada, focusing on challenges in wound management, the impact on quality of life, barriers to wound care access, and the role of traditional heali...

Global inequitable distribution of seminal studies of chemotherapy-induced nausea and vomiting

BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) remains one of the most quality of life limiting toxicities of cancer therapy. Decades of trials have produced robust antiemetic evidence, but their applicability to resource-limited settings where guideline-recommended...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Janus kinase inhibitors combined with 308‐nm excimer laser for vitiligo: A systematic review

The data that supports the findings of this study are available in the external repository (https://data.mendeley.com/datasets/6rh8dcvmfv/1) of this article.

Clinical Joint Tenderness in First-Nations First-Degree Relatives of Rheumatoid Arthritis Patients: Examining Factors Associated with Functional Disability and Progression to RA

Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting synovial joints. Prior to the clinical onset of arthritis, autoantibodies and non-specific joint symptoms often appear in the absence of joint swelling. We previously found that functional disability...