Health New Zealand

Proton Pump Inhibitor Co-prescription, Dabigatran Use, and Ischaemic Stroke or Transient Ischaemic Attack in Atrial Fibrillation: A Population-Based Case-Control Study

Proton pump inhibitors (PPIs) reduce gastric acidity and lower dabigatran plasma concentrations, raising concern about a clinically relevant drug–drug interaction. We examined whether PPI co-prescription modified the association between dabigatran use and atrial fibrillation (AF)...