Health Innovations (United States)

Red Panda Addax Optimizer_ Bidirectional Long Short-Term Memory for cluster head selection and data aggregation in wireless sensor networks

Wireless Sensor Networks (WSNs) rely on efficient data collection and transmission, where selecting an optimal Cluster Head (CH) is critical for managing energy and ensuring reliability. However, existing methods face challenges in handling dynamic network conditions, energy pred...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Environmental exposure to semi-volatile organic compounds and COPD progression: Evidence mapping, exposure assessment and metabolomic insights

Introduction Chronic obstructive pulmonary disease (COPD) progression may be influenced by non-smoking environmental exposures, especially among never-smokers and environmentally exposed populations. Semi-volatile organic compounds (SVOCs) are relevant because they persist in air...

Structural Democratization: Institutional Evolution for a Transcultural Republic

This white paper proposes a framework for structural democratization rooted in constitutionalcontinuity and institutional evolution. It begins with the recognition that representativedemocracy remains the foundation of American governance, yet its current structure including the...