Health Economics and Outcomes Research (United Kingdom)

Use of telehealth and at-home video for remote administration of the North Star Ambulatory Assessment (NSAA): a comparative methods study

Remote functional assessments can expand access and reduce burden for families affected by Duchenne muscular dystrophy (DMD), but evidence is needed on the reliability of remote administration and scoring of the North Star Ambulatory Assessment (NSAA). We conducted a non-interven...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Building recovery capital through an integrated educational and fitness substance use programme: a patient and public involvement (PPI) approach

Purpose The purpose of this study is to examine how an integrated substance use educational and fitness programme, Boxing Clever, can help to cultivate recovery capital (RC) for individuals currently or historically engaged in problematic substance use. Design/methodology/approac...

Workplace Discrimination Affecting Nurse Practitioners in US Hospitals

Background Workplace discrimination remains a concern in health care, contributing to burnout and turnover among nurses, particularly those belonging to racial and ethnic minority groups. Although evidence is growing for staff nurses, little is known about discrimination among ho...

Loneliness, not isolation, is the missing link between social connectedness and mental health among midlife to older U.S. adults

Objectives To investigate whether loneliness or social isolation serves as the main pathway connecting social connectedness dimensions to mental health outcomes among midlife to older adults.Methods We examined longitudinal data from 4,963 adults aged 40–65 at baseline in the U.S...

Live Attenuated Influenza Vaccine (LAIV) for Children for the Prevention of Influenza Illness in Sweden: A Cost-Effectiveness Analysis

Both inactivated influenza vaccine and live attenuated influenza vaccine (LAIV) (indicated for use in children aged 2–17 years) effectively prevent influenza transmission and related outcomes. Despite high transmission among children, vaccination practices in Sweden focus primari...

Incidence, prevalence, and ketoacidosis at onset of type 1 diabetes in Spain: a systematic review and critical assessment of the available evidence

The incidence, prevalence and onset of type 1 diabetes (T1D) with diabetic ketoacidosis (DKA) in Spain remain insufficiently characterized, despite multiple regional analyses. This study aims to summarize and critically assess epidemiologic data in Spain, incorporating insights f...

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence

BACKGROUND: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study compared adherence, healthcare resource utilization (HCRU),...

Real-World Effect of Ruxolitinib Cream: Decreased Use of Additional Topical Therapies and Limited Escalation to Systemic Treatments

Abstract Introduction Ruxolitinib cream has demonstrated efficacy and safety in patients aged ≥ 2 years with mild to moderate atopic dermatitis (AD) in clinical trials. Early real-world data have demonstrated results consistent with clinical trial observations and have indicated...

HIF1A-dependent induction of alveolar miR-147b dampens SARS-CoV-2-associated ARDS via direct targeting of viral RNA

BACKGROUND: Acute respiratory distress syndrome (ARDS) causes significant morbidity and mortality during viral pneumonia, including SARS-CoV-2 infections. Nevertheless, most patients with SARS-CoV-2 infections recover seamlessly without developing ARDS, suggesting the existence o...