Health Data Research UK

Clinical evaluation of AI-assisted quantitative marrow fibrosis assessment using Continuous Indexing of Fibrosis (CIF)

Abstract Assessment of fibrosis is central to the evaluation of diagnostic bone marrow trephine (BMT) biopsies. However, manual fibrosis grading is subjective and only semi-quantitative. We evaluated the clinical utility of a previously developed AI-based quantitative fibrosis as...

How many RSEs (and related roles) does it take to change a lightbulb in a cage? How RSEs are shaping UK TRE infrastructure

RSEs and related roles are critical in building secure platforms that allow researchers to access sensitive data, such as in health and social care. The gold standard for safely providing access to this data are Trusted Research Environments (TREs), also called Secure Data Enviro...

How many RSEs (and related roles) does it take to change a lightbulb in a cage? How RSEs are shaping UK TRE infrastructure

RSEs and related roles are critical in building secure platforms that allow researchers to access sensitive data, such as in health and social care. The gold standard for safely providing access to this data are Trusted Research Environments (TREs), also called Secure Data Enviro...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

The case for using flexible healthcare capacity constraints to optimize pandemic control strategies

Abstract During the COVID-19 pandemic, a key challenge was designing control strategies that balance the benefits and costs of public health measures while preventing healthcare systems from becoming overwhelmed. This was often addressed by epidemiological modellers by implementi...

Associations Between Dissociation and Childhood Trauma in Borderline Personality Disorder and Affective Disorders: A Network Analytic Approach

ABSTRACT Background Dissociation and childhood trauma are strongly associated with borderline personality disorder (BPD), yet it remains unclear whether this reflects disorder‐specific mechanisms or differences in symptom severity within a shared transdiagnostic structure. Object...