Health Commission of Anhui Province

The complete chloroplast genome sequence and phylogenetic position of Mallotus apelta

Mallotus apelta is a perennial species of Euphorbiaceae widely distributed in subtropical East and Southeast Asia. In this study, we sequenced and analyzed its complete chloroplast genome. The genome was 164,055 bp in length and exhibited a typical quadripartite structure, compri...

Endoplasmic reticulum stress promotes ferroptosis in ventilator-induced lung injury by promoting HRD1-dependent GPX4 ubiquitination via the IRE1α/XBP1 pathway

Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation. Endoplasmic reticulum stress (ERS) has been implicated in regulating ferroptosis, and we previously linked ERS to VILI-associated inflammation. However, how ERS mechanistically drives ferro...