Health and Human Development (2HD) Research Network

Ets2 Is an Activity‐Dependent Transcriptional Regulator of a Fast‐Twitch Muscle Program

The functional properties of excitable cells, including skeletal muscle, are regulated by electrical activity. Distinct motoneuron firing patterns control contraction speed, strength, and endurance of fast- and slow-twitch myofibers by activating transcriptional programs that spe...

A phosphoinositide and RAB switch controls early macropinocytosis

Macropinocytosis is a non-selective endocytic process by which cells take up large amounts of extracellular fluid into giant vesicles known as macropinosomes. This mechanism is used by immune cells to sample the surroundings for antigens and can be exploited by cancer cells for n...

Effect of Hypertension on the Health-related Quality of Life of People Living with Hypertension in Dschang, Cameroon: Comparative Analytical Cross-section

Hypertension has significant socioeconomic consequences and adversely affects the health-related quality of life (HRQOL) of people living with hypertension. In Cameroon, although one-third of adults have hypertension, no study has previously examined its impact on the HRQoL of in...

Digital maturity as a driver of innovation and competitiveness in adventure tourism operators: evidence from Portugal

The digital maturity of companies has emerged as a key determinant for competitiveness, operational efficiency and enhanced customer experience. However, research remains scarce on this topic within the adventure tourism sector. This study examines the digital maturity of adventu...

Preliminary Effects of a Multicomponent Exercise Program Delivered in Conventional and Snoezelen Rooms Among Older Women Attending Social Centers: A Non-Randomized Pilot Study

Background: The aging population in Portugal requires interventions such as multicomponent exercise to maintain the functionality of older adults. The aim of this exploratory pilot study was to investigate preliminary changes in body composition, physical fitness, quality of life...

The viral load suppression and determinants among individuals excluded from the NAMSAL clinical trial: a retrospective cohort study in Yaoundé, Cameroon

The NAMSAL (New Antiretroviral and Monitoring Strategies in Adults living with HIV in Low-income countries) trial was conducted in Yaoundé, Cameroon, to evaluate optimized antiretroviral treatment strategies. However, little is known about virological outcomes among individuals e...

Participant attrition in a multi-regional population-based study in Africa: insights from the AWI-Gen study

Attrition in longitudinal studies, defined as the loss of participants over time, may threaten the validity of study results. This study examined patterns, magnitude, and risk factors for attrition in the AWI-Gen cohort. The study included 12,032 participants from six African sit...