Harvard Stem Cell Institute

mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation

ABSTRACT Skin aging is a multifactorial process characterized by the progressive decline of tissue structure, function and regenerative capacity. Although numerous interventions have been developed to improve the clinical manifestations of aging, most primarily alleviate downstre...

A cross-species atlas platform for comparative neuroscience in teleost fish

Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structure...

Dmp1 Knock-in Mice Faithfully Report and Manipulate Dmp1 -Expressing Cells

Dentin, the primary structural component of teeth, is a mineralized tissue formed by odontoblasts, which strongly express the Dmp1 gene. Dmp1 is also expressed in osteocytes, making it a valuable marker for studying bone biology and diseases. Transgenic mouse lines expressing Cre...

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

m6A mRNA methylation regulates pancreatic α-cell plasticity

Pancreatic α-cells are central regulators of glucose and amino acid homeostasis, yet the mechanisms that preserve α-cell identity and function remain incompletely understood. N6-methyladenosine (m6A) is a widespread mRNA modification that is essential for β-cell biology and pancr...

Proliferative control of the saccular-stage developing mouse lung requires the histone methylation activity of KMT2D

KMT2D, the histone methyltransferase and core component of the COMPASS/MLL4 complex, has been implicated in developmental diseases such as Kabuki Syndrome, interstitial lung disease, and congenital diaphragmatic hernia, with clear links to pediatric pulmonary disorders. Despite t...