Harvard Global Health Institute

Neuropsychiatry genetics in Africa

Across Africa, rising mental health needs coincide with rapid advances in genomics, digital health and continental policy reform. Yet research into the genetic, environmental and social determinants of neuropsychiatric illness remains sparse and underfunded. This review argues th...

Evaluation of Intervention Strategies to Improve Follow-Up Colonoscopy After Abnormal FIT/FOBT Result

Importance Colorectal cancer is the second leading cause of cancer mortality worldwide. Early detection through screenings has been shown to improve morbidity and mortality. While fecal immunochemical test (FIT) or fecal occult blood test (FOBT) are established cost-effective scr...

Five-Year Cost-Effectiveness Analysis of Endoscopic Third Ventriculostomy With Choroid Plexus Cauterization Versus Ventriculoperitoneal Shunting in Postinfectious Hydrocephalus in a Low-Income Setting

BACKGROUND AND OBJECTIVES: For over 2 decades, an emerging body of data has established endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) as a viable option in the treatment of postinfectious hydrocephalus (PIH) in low-resource settings with similar out...

COVID-19 lockdown and coverage of maternal health and nutrition care in rural West Bengal, India: a single interrupted time-series analysis

Abstract While COVID-19 lockdowns globally disrupted healthcare, the extent of changes in India’s maternal health and nutrition services coverage in rural settings requires further empirical investigation. Utilizing data from 57,371 pregnancies recorded between January 2012 and D...

Reframing the epidemiological transition as increasing returns to tackling aging-related diseases

Abstract Global life expectancy has risen since 1973 from 58 to over 73 years, while the share of people aged 65 years and older has doubled to 10% and is projected to reach 21% by 2073. This shift is linked to an epidemiological transition from infectious to chronic disease. Her...

Estimating state-level chlamydia and gonorrhea incidence and prevalence among women living in the United States during 2019-2023: mathematical modeling analysis

Abstract Background Estimates of chlamydia and gonorrhea prevalence and incidence have typically focused on national-level epidemiology. Disaggregated estimates are useful for local public health decision making. Methods We developed a Bayesian hierarchical modeling framework to...

International migration of Africa-born health workers: a scoping review of drivers and policies, 2010–2024

Africa faces a critical shortage of human resources for health (HRH), crucial for improving population health. We described drivers of and policies to manage the migration of Africa-born HRH from source (African) countries in Africa to destination (non-African) countries. We cond...

Implementing digital health transformation policies in Latin America: insights from four national case studies

Abstract Digital health transformation (DHT) policies can improve the performance of health systems. However, there are few empirical studies on how these policies are implemented in practice. This article examines four national cases of implementing DHT policies in the Latin Ame...

Estimating Spatial and Temporal Patterns of Residential Power Outages in Massachusetts from 2013 to 2022 Using Public Records

Abstract Power outages are a growing threat to human health. Extreme weather events and strains on the electrical grid can cut off access to critical health-supporting medical equipment. However, the full scope of health impacts related to power outages has not been quantified, i...

The Impact of Isoniazid Preventive Therapy on Tuberculosis Infection and Disease Progression.

BACKGROUND: Tuberculosis (TB) causes major morbidity and mortality among children worldwide. Isoniazid preventive therapy (IPT) protects against progression to TB disease, but its effect on preventing new TB infection remains uncertain. METHODS: We conducted a longitudinal cohort...

Implementation barriers, facilitators, and fidelity of a mobile money-based savings tool for pregnant women in the Analamanga region of Madagascar: an ex-post process evaluation

Abstract Background Mobile payment services could improve access to obstetric care by easing saving, raising revenue, and pooling resources. Between 2019 and 2022, a mobile money-based savings tool for obstetric care was implemented in the Analamanga region of Madagascar followin...

A novel glyco-inflammatory healing index for risk prediction after isolated coronary artery bypass grafting: a multicenter retrospective cohort study

The Glyco-Inflammatory Healing Index (GIHI), calculated as HbA1c × C-reactive protein / albumin, integrates measures of glycemic control, systemic inflammation, and nutritional status. Its association with postoperative outcomes after isolated coronary artery bypass grafting (CAB...

A model for the epidemiological impact of tuberculosis policy options.

Objective: To develop a new tuberculosis transmission model, addressing the limitations of and building on the TB Impact Model and Estimates software tool, to enable decision-makers to assess the impact of various tuberculosis interventions and allocate resources more effectively...