Harry Perkins Institute of Medical Research

Characteristics and outcomes of patients admitted for suspected sepsis

Structured sepsis screening and management tools are associated with improvements in processes of care. Evaluating effects on clinical outcomes is challenged by the potential limitation of capturing a broader group of patients with less severe illness. The aim was to determine th...

Development and Validation of a Resting Metabolic Rate Equation for Elite Cyclists

Purpose: Accurate determination of energy expenditure (EE) in elite endurance athletes is critical for personalised nutrition strategies aimed at maintaining health and optimising performance. The resting metabolic rate (RMR) constitutes a large portion of daily EE, but existing...

Predicting recovery outcomes following mild traumatic brain injury in an Australian community cohort: Results from the Concussion Recovery Study (CREST)

Background Most people recover well following mild traumatic brain injury (mTBI). However, some experience persisting post-concussion symptoms (PPCS) for months or years. Our aims were (i) to evaluate the presence and impact of PPCS on return to functional activities over a 12-mo...

Initial Review of Government‐Funded Reproductive Carrier Screening for Cystic Fibrosis, Spinal Muscular Atrophy and Fragile X Syndrome

Summary What's already known about this topic? What does this study add?

Insight into phase-sensitive optical coherence tomography displacement measurement

Abstract Phase-sensitive optical coherence tomography (OCT) measures motion from phase differences between repeated acquisitions, supporting techniques such as Doppler OCT and optical coherence elastography (OCE). A recent numerical and experimental study showed that, even withou...

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapi...

Artificial Intelligence-Assisted Systematic Literature Reviews in Metabolic Phenotyping: A Methodological Framework and Validation Study

Abstract Systematic literature reviews are widely acknowledged to be at the top of most evidence hierarchies but are very time-consuming and labour-intensive. The advent of artificial intelligence (AI) offers possibilities to accelerate the review process. We propose a systematic...

Functional Assessment of a Constitutively Activating CASR Variant Causing Autosomal Dominant Hypocalcaemia

Abstract Context A rare cause of hypocalcaemia, autosomal dominant hypocalcaemia type 1 (ADH1) arises from a gain-of-function variant of the calcium sensing receptor gene (CASR). Objective Three patients from two unrelated families, presenting with hypocalcaemia and other biochem...