Harbin Veterinary Research Institute

ADAM17 is a broad HIV-1 restriction factor targeted by Nef to restore Env maturation

HIV-1 uses the accessory protein Nef to enhance the infectivity of newly produced virus particles, but the host defenses counteracted by Nef remain incompletely defined. The membrane protein SERINC5 contributes to this defense but primarily restricts laboratory-adapted HIV-1 stra...

Research on Disturbance Control of Electro-Hydraulic Servo Systems Based on Fractional-Order Sliding Mode Control

To improve the disturbance rejection performance of valve-controlled cylinder electro-hydraulic servo systems under external disturbances and load variations, this paper proposes a fractional-order sliding mode control (FOSMC) strategy. A system model with dual-inertia compensati...

PRRSV infection induces mitochondrial damage and releases mitochondrial dsRNA to activate the NLRP3-dependent inflammatory response

Abstract Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), remains one of the most economically significant infectious diseases affecting the global swine industry, resulting in annual losses exceeding US $1.2 billion in the USA alone. PRRSV...

A single-cell profile of the porcine immune repertoire: concurrent profiling of T cell receptor and B cell receptor V(D)J sequences in health

Adaptive immune diversity is shaped by the complex organization of T cell receptor (TCR) and B cell receptor (BCR) repertoires across tissues. However, a systematic cross-tissue immune repertoire profiling in healthy pigs is still lacking. In this study, we used 3 14-day-old Duro...

MOV10 inhibits SADS-CoV replication by enhancing TRIM24-mediated K63-linked TRAF3 ubiquitination, and this inhibition is antagonized by viral N protein

), is a novel coronavirus that causes acute diarrhea, vomiting, and high mortality in suckling piglets. Innate immunity plays a crucial role in defending the host against invading pathogens. Previous studies have identified several host factors that inhibit SADS-CoV replication t...

Unique amino acid substitution within the spike glycoprotein S1 subunit promotes infectious bronchitis virus infection via enhancing viral attachment

ABSTRACT Due to the scarcity of cell-adapted strains and limitations of current reverse genetics techniques, the factors determining cell tropism of infectious bronchitis virus (IBV), a prototype gammacoronavirus , remain unclear. Here, we demonstrated that the expanded cell trop...

Development and Validation of an Antigen-Capture ELISA for Quantitative Detection of Donkey-Origin Rotavirus: Application in Vaccine Manufacturing Process Monitoring

Rotavirus A (RVA) causes severe diarrhea in donkey foals, but rapid quantitative antigen assays for vaccine development and manufacturing control are lacking. We developed a VP6-based antigen-capture ELISA (acELISA) for donkey-origin RVA using rabbit anti-RVA polyclonal IgG as th...

Prolonged exposure to atrazine through drinking water facilitates splenic apoptosis and induces exhaustion-like checkpoint upregulation in mice

Atrazine (ATR) is a widely used herbicide that persists in aquatic environments, raising concerns regarding its long-term immunotoxicity. As a central immune organ, the spleen represents a potential toxicological target, yet the impact of prolonged ATR ingestion via drinking wate...