Hanzhong Central Hospital

Association of neoadjuvant subcutaneous trastuzumab with higher pathological complete response in HER2-positive breast cancer: a real-world doubly robust study

Randomized trials have demonstrated the non-inferiority of subcutaneous (SC) versus intravenous (IV) trastuzumab. Its association with pathological complete response (pCR) in routine neoadjuvant practice warrants further study. The ability of serial ultrasound measurements to dis...

Robust multi-label ECG classification: a deep learning framework for concurrent arrhythmias with clinical generalizability

Electrocardiogram (ECG) signals play a critical role in the clinical screening and diagnosis of various cardiovascular diseases. Although computer-aided diagnostic technologies have alleviated the burden on clinicians, the variability, complexity, and class imbalance of ECG data...

Complete mitochondrial genome assembly and comparative analysis of the endangered species Petrocosmea qinlingensis

Petrocosmea qinlingensis W. T. Wang (Gesneriaceae) is an endemic species from the Qinling Mountains of China . This species has a restricted distribution and a small population size and has been designated as a National Grade II Protected Plant in China. It has attracted taxonomi...

Correlation between CYP2B6 exonic gene polymorphisms and efavirenz plasma concentrations in Yi ethnic HIV/AIDS patients: a study from Sichuan province, China

Polymorphisms in the CYP2B6 Gene significantly impact efavirenz (EFV) metabolism and plasma levels, resulting in variability in both treatment effectiveness and toxicity among individuals. In this study, we aimed to evaluate the relationship between the CYP2B6 polymorphisms and t...

Design and fabrication of a multifunctional Zn-Fe@Ag nanocomposite for effective treatment of infections wounds

<title>Abstract</title> Infectious wounds, a common bacterial infection in clinical practice, often experience significantly delayed healing due to local bacterial colonization, macrophage polarization imbalance, and tissue regeneration inhibition, posing persistent challenges fo...