Hannover Re (Germany)

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

Sex-specific patterns of symptom burden, psychological distress, and work productivity impairment in post-acute sequelae of COVID-19: a 10-month dynamic cohort study

Abstract Background A considerable proportion of patients experience post-acute sequelae of COVID-19 (PASC). Increasing evidence suggests sex-related differences, yet systematic longitudinal analyses remain limited. This study aimed to examine sex-specific differences in symptoms...

Vibration serviceability assessment and vibration mitigation of through-truss footbridges in Iran under human-induced excitation

This study evaluates the vibration serviceability of widely implemented steel through-truss footbridges in Iran, with a detailed analysis of three representative case studies. Numerical models are developed to assess natural frequencies and maximum accelerations induced by pedest...

Quantum optimization for the warehouse layout problem

Abstract The warehouse layout problem (WLP), also known as warehouse slotting problem, aims to determine the assignment of products to storage locations while minimizing the total travel distance for picking operations. It is combinatorial in nature and well-known to be NP-hard....