Institution
Hangzhou Institute of Medicine, Chinese Academy of Sciences
Recent research
- Biology
Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met
Abstract Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targe...
- Biology
Abstract Ovarian cancer, the most lethal gynecologic malignancy, urgently demands early and accurate diagnostic methods. Tumor-derived extracellular vesicles (tEVs) hold great promise as noninvasive biomarkers, yet their clinical translation is severely hampered by inherent heter...
- Health & Medicine
Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmabl...
- Biology
Abstract Oral biomaterials capable of protecting natural bioactives during gastrointestinal transit while restoring intestinal barrier function offer a promising strategy for inflammatory bowel disease intervention. Here, we developed edible Jelly Fig (Ficus awkeotsang Makino, JF...
- BiologyOpen access
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...