Hangzhou Hospital of Traditional Chinese Medicine

Association of the dietary carbohydrate-to-fiber ratio with prevalent rheumatoid arthritis in NHANES 2009–2018

This study examines the cross-sectional association between the carbohydrate-to-fiber ratio (CFR), an indicator of carbohydrate quality, and prevalent rheumatoid arthritis (RA) in the National Health and Nutrition Examination Survey (NHANES). The exposure was overall CFR, calcula...

Differential effects of Qingre Lishi formula on serum total bile acid and liver function markers in early- and late-onset intrahepatic cholestasis of pregnancy

This study aimed to explore the differential intervention effect of Qingre Lishi formula on serum total bile acid and liver function markers in patients with early-onset and late-onset intrahepatic cholestasis of pregnancy (ICP), and to provide a basis for clinical classification...

Ultrasound‐Responsive Extracellular Vesicle‐Encapsulated Piezoelectric Nanoparticles for Chronic Inflammatory Pain Suppression

ABSTRACT Chronic inflammatory pain is characterized by the long‐term coexistence of central sensitization and neuroinflammation. Electrical stimulation has been demonstrated to be an effective strategy for alleviating chronic inflammatory pain. However, implanted electrodes have...

CAR-based therapies in systemic autoimmunity: from deep immune depletion toward durable immune reset

Systemic autoimmune diseases are sustained by self-renewing networks of autoreactive B cells, antibody-secreting cells, pathogenic T-cell programs and tissue-resident inflammatory niches. Conventional immunosuppression and biologic therapy can reduce disease activity, but often f...

AI-Assisted rational enzyme engineering: advancing biocatalysis for industrial applications

The emergence of artificial intelligence (AI) has initiated a paradigm shift in enzyme engineering. While traditional methods like directed evolution and rational design are proven, they often suffer from limited predictive power, scalability, and efficiency. The integration of A...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

Prediction of the Efficacy of PA-TACE in Patients with Clearly Defined Hepatocellular Carcinoma by Imaging Combined with Serology: A Retrospective Cohort Study with a Two-Center Follow-Up of up to 12 Years

Objective: The purpose of this study was to determine which patients with hepatocellular carcinoma (HCC) actually benefit from Postoperative adjuvant Transarterial chemoembolization (PA-TACE) and to develop a reliable predictive model for tailored treatment choices. Methods: A to...

Candidate Spatial Niches Associated with Gastric Cancer Metastasis and Treatment Resistance: Functional Classification, Evidence Boundaries, and a Translational Framework

Gastric cancer metastasis and poor treatment responses are spatially heterogeneous; however, single-marker positivity, cellular enrichment, or simple colocalization alone is insufficient to establish a functionally meaningful spatial niche. Within this framework, “treatment resis...

Weight regain following discontinuation of glucagon-like peptide-1 receptor agonists in adults who are overweight or obese: a systematic review and meta-analysis

Objective This study aims to explore the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on weight changes and the occurrence of adverse reactions in overweight or obese adults after drug withdrawal. Methods Computerized searches were conducted in evidence-based d...

Thermogenic adipose tissue as a therapeutic target: from human heterogeneity to pharmacological translation

Thermogenic adipose tissue, including classical brown adipose tissue (BAT) and inducible beige adipocytes, has re-emerged as a promising therapeutic target in the obesity field. Because BAT can convert chemical energy into heat while also playing a role in regulating systemic glu...

Vitamin D in spine disorders: mechanisms, clinical evidence, and translational gaps—a narrative review

Vitamin D has been increasingly implicated in the pathophysiology of spine disorders, yet its clinical utility remains uncertain. Across a broad spectrum of conditions, including intervertebral disc degeneration, chronic low back pain, lumbar spinal stenosis, spinal deformities,...

P53 Competitively Binds P300 to Suppress HIF ‐1α/ TFRC ‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

ABSTRACT Doxorubicin (DOX) resistance limits the efficacy of chemotherapy in breast cancer, and suppression of ferroptosis may contribute to this process. This study investigated the role of the Tumor Protein P53 (P53)/E1A‐associated protein P300 (P300)/Hypoxia‐inducible factor‐1...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Mechanistic roles of the NLRP3–caspase-1 signaling axis in atherosclerosis: pyroptosis, interaction networks, and therapeutic targets

Atherosclerosis (AS) is a chronic inflammatory condition marked by lipid and immune cell accumulation in arteries, leading to plaque formation and vascular dysfunction. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammaso...