Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine

UBE2K-FBXO11 complex activates Wnt signaling by stabilizing β-catenin through lysine 63-linked polyubiquitination

Abstract Β-catenin is regulated by phosphorylation and lysine (K)48-linked ubiquitination, which target it for proteasomal degradation. While the degradation machinery of β-catenin, including the destruction complex, has been extensively studied, regulators that stabilize β-caten...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Gastrointestinal-Responsive Jelly Fig–Alginate Microgels for Restoring Intestinal Barrier Homeostasis through Microbiota–Metabolite Remodeling

Abstract Oral biomaterials capable of protecting natural bioactives during gastrointestinal transit while restoring intestinal barrier function offer a promising strategy for inflammatory bowel disease intervention. Here, we developed edible Jelly Fig (Ficus awkeotsang Makino, JF...

Forecasting influenza A and B positive case counts using a hybrid seasonal autoregressive integrated moving average and long short-term memory (SARIMA-LSTM) model: an epidemiological study from Jiande, Hangzhou, China

Influenza A and B impose substantial public-health burdens. Using hospital- based laboratory-confirmed surveillance data, this study aimed to characterise the epidemiological features of influenza A and B cases and forecast their temporal trends, so as to provide evidence for inf...

Synergistic microbiologically influenced corrosion of SLM TC4 by co-culture of Streptococcus mutans and Veillonella dispar

Ti-6Al-4V (TC4) is extensively utilized for oral implants due to its excellent mechanical properties and biocompatibility. In the oral environment, microbiologically influenced corrosion (MIC) is typically driven by multispecies biofilms. Here, electrochemical, surface, and corro...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Ultrasound-activated Cu2−XSe/TiO2 heterostructured nanosonosensitizer enables coordinated induction of ferroptosis and cuproptosis for tumor immunotherapy

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of actionable molecular targets, high metastatic propensity, and limited responsiveness to current immunotherapies. Although immune checkpoint inhibitors show promise, their clinical...

Surgical strategy for hemifacial spasm caused by vertebrobasilar dolichoectasia: interposition technique versus transposition technique

This study aimed to retrospectively evaluate clinical outcomes, recurrence, and complications associated with interposition and transposition techniques for the management of vertebrobasilar dolichoectasia (VBD) in patients with hemifacial spasm (HFS). We retrospectively reviewed...

Applications of the multi-process action control framework in physical activity promotion: a scoping review

The “intention-behavior gap” represents a core bottleneck in the failure of health behavior interventions, with traditional theories offering insufficient explanations for the dynamic mechanisms from intention formation to behavior maintenance. The Multi-Process Action Control (M...

Expression of key factors in the TGF-β1/Smad2 pathway and their associations with clinicopathological characteristics and prognosis in HBV-associated hepatocellular carcinoma

Abstract Background This study investigated the expression of TGF-β1 and Smad2 in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) and evaluated their associations with clinicopathological characteristics and prognosis. Methods In this prospective single-center c...

Tissue Olink Proteomics Analysis Reveals CCL17 as a Potential Biomarker in Patients With Pressure Ulcers

ABSTRACT Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this...

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

Implementation of an emergency nursing pathway reduces emergency department length of stay in trauma

Timely, organized emergency care is critical for patients with severe trauma, particularly in primary hospitals where resources and workflows may be constrained. This study evaluated the effect of implementing an emergency nursing pathway (ENP) on emergency management of injured...

The imaging features of neurovascular compression in hemifacial spasm patients

Neurovascular compression is considered the main cause of primary hemifacial spasm. However, it also occurs on the asymptomatic facial nerves in primary hemifacial spasm patients and in healthy controls. This study aimed to compare neurovascular compression features among the thr...

Deep learning radiomics based on preoperative multiparametric MRI in predicting breast cancer recurrence risk

Breast cancer treatments are often tailored to recurrence risk to improve outcomes, but reliable risk stratification methods are lacking. To predict preoperative breast cancer recurrence risk through a tridimensional synergy model integrating breast MRI, radiomics, and deep learn...

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

High immunosuppressants variability adversely affects post-transplant recurrence for patients with hepatocellular carcinoma

Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) is the most significant obstacle impacting the prognosis of patients. Managing the clinical application of immunosuppressive agents is difficult, owing to their limited therapeutic range and nota...

Mechanisms and Clinical Assessment of Fear of Disease Progression in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive, life-limiting neurodegenerative disease characterized primarily by motor dysfunction, although cognitive and behavioral impairment occurs in a substantial subset of patients. Progressive functional decline and prognostic uncer...