Hangzhou First People's Hospital

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

Multidisciplinary diagnosis and treatment of lingual thyroid presenting as hematemesis

Rationale: Hematemesis is a common symptom of gastrointestinal disorders and is often associated with upper gastrointestinal issues. However, lingual thyroid, a rare ectopic thyroid condition, can also present with hematemesis, complicating diagnosis and increasing the risk of mi...

Innovative treatment strategies for impacted maxillary central incisor and case comparisons

Background: The present article compares innovative treatment strategies for impacted maxillary central incisors, emphasizing the critical importance of prioritizing root development over rapid crown alignment. Methods: Two case reports using distinct clinical approaches are pres...

Influence of Isokinetic Muscle Strength Training Combined With Early Functional Exercise on Joint Function After Knee Cruciate Ligament Reconstruction

AIM: The purpose of this study was to evaluate and analyze the influence of isokinetic muscle strength training combined with early functional exercise on joint function after knee cruciate ligament reconstruction.METHODS: A total of 294 patients undergoing knee cruciate ligament...

Predictive Value of the Systemic Immune-Inflammation Index Combined With the Prognostic Nutritional Index for Flap-Related Complications Following Flap Repair in Patients With Stage Ⅲ and Ⅳ Pressure Injuries

AIM: To investigate the combined predictive value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for postoperative flap-related complications in patients with stage Ⅲ and Ⅳ pressure injuries undergoing flap repair.METHODS: A single-center retro...

Exploring the molecular pathways of Noncoding RNAs in ovarian cancer: insights into treatment resistance

Ovarian cancer ranks as the third most common gynecological malignancy, yet it has the highest mortality and recurrence rates among all gynecologic cancers. Chemotherapy combined with immunomodulators and targeted agents, including PTX, ADR, PARPi, and platinum-based chemotherape...

Consistency of urethroscopy vs. high-frequency ultrasound in diagnosing male urethral condyloma acuminatum

Abstract Objectives Urethral condyloma acuminatum(CA) is characterized by hidden growth, high treatment difficulty, high recurrence rate, and significant harm. Urethroscopy is a traditional method for examining male urethral CA. As a safe, non-invasive, highly reproducible, and c...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections

CD8 T cells are critical players in immune responses against pathogens. Interleukin-21 (IL-21) is predominantly produced by CD4 T cells and exerts multifaceted effects on CD8 T cell regulation and function. Using Il21 -reporter and Il21 –fate mapping mice, we report that a subpop...