Hangzhou Children's Hospital

Performance of the axial length-to-corneal radius ratio in distinguishing pre-myopia from hyperopia under cycloplegia in school-aged children: an age-stratified retrospective cross-sectional study

The axial length/corneal radius (AL/CR) ratio is an established structural indicator of myopia, but its ability to discriminate within the non-myopic range—specifically pre-myopia from hyperopia under cycloplegia—remains poorly characterised. We aimed to evaluate the performance...

Invasive Pneumococcal Disease in Children: A Retrospective Three-Center Study in Zhejiang Province, China (2010–2024)

Invasive pneumococcal diseases (IPD) are among the leading causes of global child mortality. Pneumococcal conjugate vaccines provide direct protection against IPD caused by serotypes included in the vaccine. To investigate the clinical characteristics, serotypes, and antibiotic r...

Type VI secretion system genes sciG and sciS facilitate biofilm formation of Salmonella enterica serovar Typhi

Biofilm formation is a crucial survival strategy for Salmonella enterica serovar Typhi ( S. Typhi), enabling it to withstand adverse environmental conditions and host immune responses. This process is tightly regulated by complex genetic networks. The type VI secretion system (T6...

Upper-airway organism detection profiles in children with respiratory tract infection assessed by targeted next-generation sequencing: a single-centre descriptive study in Changzhou, China, August 2022 to March 2024

Respiratory tract infection (RTI) is among the commonest reasons for children to seek medical care, and the spectrum of organisms detected in the airway may shift with epidemic-prevention policies and with the epidemic cycles of individual organisms. This study describes the prof...

Defining a minimal clinically important difference for the Vanderbilt ADHD Parent Rating Scale in children with Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition in children and adolescents that poses substantial challenges to health, functioning, and well-being. This study aimed to estimate the minimal clinically important difference (MCID) for th...