Handan College

The diagnostic and prognostic value of serum FBXO11 expression in neonatal sepsis

This study aimed to investigate the correlation between serum FBXO11 expression and serum PCT and CRP levels as well as its diagnostic and prognostic value in neonatal sepsis (NS). This study included 120 patients with NS aged ≤ 28 days, birth weight > 2500 g, and gestational age...

Evaluation of the efficacy and safety of different cycles of neoadjuvant chemotherapy combined with immunotherapy in locally advanced esophageal squamous cell carcinoma: a multi-center, real-world study

Neoadjuvant chemotherapy combined with immunotherapy (nCIT) can improve radiologic and pathological responses in resectable, locally advanced esophageal squamous cell carcinoma (ESCC), yet the optimal number of preoperative cycles is unknown. We conducted a multicenter, real-worl...

Dynamic evolution of chaperone-mediated autophagy is associated with tumor microenvironment remodeling and prognostic stratification in lung adenocarcinoma: insights from single-cell transcriptomics, ensemble machine learning, and experimental validation

BACKGROUND: Lung adenocarcinoma (LUAD) shows prognostic heterogeneity, and tumor-node-metastasis (TNM) staging is limited for individualized management. Chaperone-mediated autophagy (CMA) maintains proteostasis, but its role during adenocarcinoma in situ (AIS)-minimally invasive...