Handan College

Comparative efficacy of two novel bioceramic root canal sealers in the treatment of chronic apical periodontitis

Chronic apical periodontitis (CAP) is a persistent periradicular inflammatory condition driven by intraradicular infection and remains a common indication for primary nonsurgical root canal therapy. This retrospective cohort study compared 2 calcium silicate-based bioceramic root...

Surface Potential Well‐Gated Piezocarrier Escape for Reversible Oxygen Redox in Lithium–Oxygen Chemistry

ABSTRACT Piezocatalysis offers a promising way to harness intrinsic mechanical energy for accelerating sluggish oxygen redox reactions in lithium–oxygen batteries. However, its efficiency depends not just on piezoelectric polarization strength, but critically on whether stress‐in...

Integrative analysis and external validation identify a novel seven-gene signature for preeclampsia risk stratification

Placental transcriptomic alterations play a critical role in the pathophysiology of preeclampsia (PE), yet robust gene signatures for risk stratification remain underexplored. We first integrated four GEO datasets (GSE75010, GSE25906, GSE24129, and GSE10588). Using the GSE75010 d...

Glioblastoma mimicking a cerebral cavernous malformation: case report

Glioblastoma is the most common malignant tumor of the central nervous system, and its diagnosis is typically straightforward based on clinical and neuroimaging data. However, when glioblastoma and cavernous hemangioma exhibit overlapping MRI features, the diagnosis becomes chall...

Effects of reduced gluten intake through the inclusion of yellow pea-based products on abdominal symptoms in habitual wheat consumers: a non-randomized clinical trial

Abstract Purpose Increasing attention has been paid to individuals who report gastrointestinal symptoms following wheat consumption. In addition to wheat allergy and celiac disease, non-celiac gluten sensitivity (NCGS) has been proposed as a clinical entity. Despite persistent sy...

The diagnostic and prognostic value of serum FBXO11 expression in neonatal sepsis

This study aimed to investigate the correlation between serum FBXO11 expression and serum PCT and CRP levels as well as its diagnostic and prognostic value in neonatal sepsis (NS). This study included 120 patients with NS aged ≤ 28 days, birth weight > 2500 g, and gestational age...

Evaluation of the efficacy and safety of different cycles of neoadjuvant chemotherapy combined with immunotherapy in locally advanced esophageal squamous cell carcinoma: a multi-center, real-world study

Neoadjuvant chemotherapy combined with immunotherapy (nCIT) can improve radiologic and pathological responses in resectable, locally advanced esophageal squamous cell carcinoma (ESCC), yet the optimal number of preoperative cycles is unknown. We conducted a multicenter, real-worl...

Dynamic evolution of chaperone-mediated autophagy is associated with tumor microenvironment remodeling and prognostic stratification in lung adenocarcinoma: insights from single-cell transcriptomics, ensemble machine learning, and experimental validation

BACKGROUND: Lung adenocarcinoma (LUAD) shows prognostic heterogeneity, and tumor-node-metastasis (TNM) staging is limited for individualized management. Chaperone-mediated autophagy (CMA) maintains proteostasis, but its role during adenocarcinoma in situ (AIS)-minimally invasive...