Hammersmith Hospital

Ovarian Cyst Fluid as a Resource for Diagnostic and Prognostic Biomarker Discovery in Ovarian Lesions

Background/Objectives: Differentiating benign, borderline, and malignant ovarian cystic lesions before surgery remains challenging, and many women undergo operations for lesions that prove benign. Most cystic lesions contain fluid that lies in direct contact with the lesion and f...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry

Abstract Aims The right ventricle (RV) is a major determinant of outcome in pulmonary arterial hypertension (PAH), but its assessment has not been completely incorporated in the risk of mortality scores. We therefore evaluated the added value of echocardiography of the RV to risk...

Plasma membrane order maps functional diversity in immune cells

Abstract Cell membranes undergo biophysical remodeling as an adaptation to the surroundings and to perform specific biological functions. However, the extent and relevance of such changes in human immune cells remain unknown, largely because of the lack of single-cell and multidi...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Kidney transplantation in older people (KTOP): a longitudinal, qualitative study of kidney transplant experiences in older, frail adults

Abstract Background Transplantation rates are increasing in those who are older and frail, driven by an aging dialysis population. This longitudinal, qualitative study explores how older adults navigate the journey from dialysis to transplantation and how frailty is experienced a...

Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers

Abstract iNKT cells are emerging as a highly promising immunotherapy platform for the treatment of cancer. To maximise the anti-cancer activity of CAR-iNKT against the blood cancer multiple myeloma we investigated optimal CAR designs and their combination with new iNKT-specific e...

In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is the most common malignancy occurring in people living with HIV (PLWH). The clinical course of KS in PLWH established on combined anti-retroviral therapy (cART) resembles that of classic KS. OBJECTIVES: To compare the clinical and biological ch...

The influence of hypoxia on cancer lipid metabolism: a scoping review

Abstract Background Hypoxia, a hallmark of solid tumours, profoundly alters cellular metabolism to enable survival in the harsh tumour microenvironment. Whilst effects on carbohydrate and protein metabolism are well characterised, the hypoxic regulation of lipid metabolism remain...

Iron deficiency testing among people with incident heart failure in primary care

Background Given around 50% of people with heart failure have a degree of iron deficiency, guidelines recommend screening. It is uncertain to what extent this is done in primary care and whether testing is equitable. Aim To report the proportion of people with incident heart fail...