Hamamatsu University School of Medicine

Temporal dissection of hepatitis C virus and orthoflavivirus infections by continuous luminescence monitoring

Virus infection is a dynamic process consisting of rapidly evolving viral and host events, yet conventional endpoint assays provide only fragmented snapshots of these processes. Here, we established a unified temporal framework for dissecting virus-host interactions by integratin...

Contrasting roles of PD-L1 expression in tumor and stroma: Biological and prognostic implications in esophageal squamous cell carcinoma.

Programmed death-ligand 1 (PD-L1) plays a central role in immune regulation in esophageal squamous cell carcinoma (ESCC) and has been widely used as a biomarker for immune checkpoint inhibitor therapy. However, the biological and clinical significance of PD-L1 expression remains...

Low baseline Tc-MEP amplitude is associated with false-positive alerts in spine surgery: a ROC-based analysis across spinal pathologies

This study aimed to determine whether absolute baseline transcranial motor evoked potential (Tc-MEP) amplitude is associated with false-positive (FP) alerts during intraoperative neurophysiological monitoring and to estimate pathology-specific cutoff values. We retrospectively re...

Successful Cytotoxic Chemotherapy‐Free Bridging to Hematopoietic Stem Cell Transplantation With Dasatinib and Prednisolone/Blinatumomab for Relapsed Pediatric Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

The authors declare no conflict of interest. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the artic...

Incidence of and Risk Factors for Immune Checkpoint Inhibitor-Related Pneumonitis in Thoracic Malignancies: A Prospective Multicenter Study

Abstract Background Immune checkpoint inhibitors (ICIs) have fundamentally changed cancer treatment, but ICI-related pneumonitis (ICI-P) remains a major clinical concern. Although numerous studies have reported its incidence and risk factors, the retrospective nature of these stu...

Association between place of death and regional variation in senility mortality in Japan: a nationwide ecological study

Abstract Background In recent years, senility mortality has increased substantially in Japan, accounting for 12.9% of all deaths in 2024. Although senility (International Classification of Diseases, Tenth Revision, code R54) is often regarded as a non-specific cause of death in i...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Impact of baseline renal function on the clinical outcomes and safety of adjuvant nivolumab in high-risk urothelial carcinoma: a multicenter retrospective real-world study

Abstract Background Adjuvant nivolumab prolongs disease-free survival (DFS) in patients with urothelial carcinoma (UC) after radical surgery; however, evidence in those with reduced baseline renal function is limited. We investigated the impact of baseline creatinine clearance (C...

Development of a prognostic model for elderly patients with metastatic clear cell renal cell carcinoma treated with first-line immuno-oncology combination therapy.

BACKGROUND: In the era of immuno-oncology (IO) combination therapy, prognostic tools for elderly patients with metastatic clear cell renal cell carcinoma (ccRCC) are lacking. This study aimed to identify prognostic factors in elderly patients and evaluate a novel risk model using...

Incident in-hospital sarcopenia after pancreaticoduodenectomy: A single-center retrospective observational study

Backgrounds/Aims: Incident sarcopenia after pancreaticoduodenectomy (PD) can negatively impact postoperative recovery, but its occurrence during hospitalization has not been well documented. This study aimed to describe operationally defined incident in-hospital sarcopenia after...

Minimally invasive cardiac surgeries in 2023–annual report of the Japanese association for minimally invasive cardiac surgery

Abstract Objective To establish updated nationwide perioperative benchmarks for minimally invasive cardiac surgery (MICS) in Japan by presenting the 2023 annual report and summarizing procedural trends from 2021 to 2023. Methods Data on mitral valve (MV) surgery, aortic valve rep...

MIT / TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

BACKGROUND: Transcription factors of the MIT/TFE family-mitfa, mitfb, and tfec-play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but la...

Real‐World Outcomes of Olaparib in Japanese Patients With BRCA ‐Mutated Metastatic Castration‐Resistant Prostate Cancer: Exploratory Analysis of BRCA2 Loss and Microsatellite Instability Status

OBJECTIVES: Metastatic castration-resistant prostate cancer has a poor prognosis. Although olaparib has demonstrated efficacy in patients with BRCA1/2 mutations, real-world data in Japanese patients remain limited. We aimed to evaluate the efficacy and safety of olaparib in patie...

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surger...

P1.186. Clinical Utility of Robot-Assisted Esophagectomy Based on Short- and Long-Term Outcomes

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Our department introduced thoracoscopic esophagectomy in the left lateral–prone hybrid position (MIE) in 2017 and robot-assisted thoracoscopic esophagectomy (RAMIE) in the semi-prone position usi...

P1.203. Evaluation of the Usefulness of Robot-Assisted Esophagectomy Compared to Thoracoscopic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Following the results of the JCOG1409 trial, thoracoscopic esophagectomy has become the standard treatment for esophageal cancer. However, the introduction of r...

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite sec...