Hamamatsu University

Temporal dissection of hepatitis C virus and orthoflavivirus infections by continuous luminescence monitoring

Virus infection is a dynamic process consisting of rapidly evolving viral and host events, yet conventional endpoint assays provide only fragmented snapshots of these processes. Here, we established a unified temporal framework for dissecting virus-host interactions by integratin...

Contrasting roles of PD-L1 expression in tumor and stroma: Biological and prognostic implications in esophageal squamous cell carcinoma.

Programmed death-ligand 1 (PD-L1) plays a central role in immune regulation in esophageal squamous cell carcinoma (ESCC) and has been widely used as a biomarker for immune checkpoint inhibitor therapy. However, the biological and clinical significance of PD-L1 expression remains...

Low baseline Tc-MEP amplitude is associated with false-positive alerts in spine surgery: a ROC-based analysis across spinal pathologies

This study aimed to determine whether absolute baseline transcranial motor evoked potential (Tc-MEP) amplitude is associated with false-positive (FP) alerts during intraoperative neurophysiological monitoring and to estimate pathology-specific cutoff values. We retrospectively re...

Successful Cytotoxic Chemotherapy‐Free Bridging to Hematopoietic Stem Cell Transplantation With Dasatinib and Prednisolone/Blinatumomab for Relapsed Pediatric Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

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Longitudinal Immunophenotypic Changes in Refractory Lupus Nephritis After B-cell Depletion: A 25-year Case Study

Background/Aim: Long-term management of systemic lupus erythematosus (SLE) requires a persistent balance between intensive immunosuppression and the prevention of opportunistic infections. This is particularly challenging in patients with a multi-decade disease history and evolvi...

P1.216. Investigation of Lemborexant for Prevention of Postoperative Delirium Following Subtotal Thoracic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Postoperative delirium and sleep disturbances after surgery for gastrointestinal malignancies greatly affect patients' quality of life. Postoperative delirium i...

P1.186. Clinical Utility of Robot-Assisted Esophagectomy Based on Short- and Long-Term Outcomes

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Our department introduced thoracoscopic esophagectomy in the left lateral–prone hybrid position (MIE) in 2017 and robot-assisted thoracoscopic esophagectomy (RAMIE) in the semi-prone position usi...