Hainan General Hospital

Towards a structure-aware multi-hop retrieval framework for large language model reasoning over complex oncology guidelines

Large language models (LLMs) augmented with clinical guidelines show promise in medical question answering, yet structural parsing and evidence retrieval over complex guidelines remain challenging. We propose SMART-RAG (Structure-aware Multi-hop Augmented Retrieval Technique for...

Preliminary metabolomic and genomic exploration with gene-expression validation in multiple symmetric lipomatosis

Abstract Background Multiple symmetric lipomatosis (MSL) is a rare disorder of fat metabolism with an incompletely understood pathogenesis and limited treatment options. This preliminary study explored metabolite differences and genomic characteristics in paired lesional and adja...

Interpretable machine learning-based model for predicting postoperative urinary tract infection after minimally invasive surgery for upper urinary tract calculi: development and external validation

This study sought to develop and externally validate an interpretable machine learning–based model to predict the risk of urinary tract infection (UTI) following minimally invasive surgery (MIS) in patients with upper urinary tract calculi. Clinical data from patients suffering u...

CRISPR-mediated recombinase-assisted amplification for hazard assessment of Vibrio parahaemolyticus on microfluidic system

Highly sensitive and accurate detection of virulence and drug resistance genes in Vibrio parahaemolyticus ( V. parahaemolyticus ) is essential for disease prevention and the control of foodborne transmission. In this research, a novel RAA-CRISPR/Cas12a-based microfluidic hazard a...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Sleep quality is associated with gut microbiome signatures of hyperuricemia in Chinese elderly adults: a community-based case–control study

Hyperuricemia (HUA) has become a global health issue due to its rapidly increasing prevalence. Growing evidence from population and animal studies suggests that gut microbial dysbiosis and lifestyle changes are involved in serum uric acid metabolism. However, most existing studie...

Treatment of bleeding from endogenous heparin-like substances after traumatic injury with protamine: a case report

Abstract Background To provide reference for clinical treatment of trauma-induced coagulopathy. Persistent bleeding caused by endogenous heparin-like substances is difficult to identify and diagnose. This report describes the clinical manifestations and management of patients wit...

Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing

Infected wounds represent a significant clinical burden owing to persistent infection, excessive inflammation, and impaired tissue regeneration. To overcome these limitations, we developed a sprayable N-succinyl chitosan/Pluronic F127 (NSC/PF127) hydrogel incorporating MoO₂ nanop...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Communication support for older adults with age-related hearing loss in acute care settings

Age-related hearing loss is frequently overlooked in acute care settings despite its negative effects on communication, care experience and patient safety. This literature review synthesises recent evidence on interventions, practices and approaches relevant to supporting older a...

The relationship between preoperative anxiety, self-efficacy, and positive coping style in lung cancer patients undergoing video-assisted thoracoscopic surgery: a cross-sectional study

Abstract Background Patients with lung cancer undergoing video-assisted thoracoscopic surgery (VATS) may experience preoperative anxiety arising from cancer-related uncertainty and surgery-related concerns. Although VATS is less invasive than conventional thoracotomy, patients ma...

Body composition, sarcopenia, and frailty among Northern seasonal migrant older adults: a cross-sectional study

Abstract Background To provide preliminary data on body composition, muscle health, nutritional status, and frailty among seasonal migrant older adults who overwinter in Hainan, and to identify potential health risks in this growing mobile aging population. Methods A cross-sectio...

Analysis of the prevalence of positivity for tuberculosis infection in formalin-fixed paraffin-embedded tissue

Abstract Background The objective of this study was to analyze the tuberculosis(TB) positivity rate of formalin-fixed paraffin-embedded (FFPE) tissue samples, to explore the difference between the positivity rates of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (E...

Association between operative duration and prolonged intensive care unit stay for more than 24 h in lung cancer patients following thoracoscopic lobectomy: a retrospective cohort analysis

Lung cancer remains the primary cause of cancer-related mortality worldwide. While prolonged operative duration is increasingly recognised as a modifier of surgical risk, its independent association with prolonged intensive care unit (ICU) stay for more than 24 h following thorac...