Haikou City People's Hospital

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

tACS and nervonic acid inhibit microglial overactivation via the Rap1 signaling pathway and ameliorate sleep deprivation-induced cognitive impairment

Sleep deprivation (SD) has become a critical global health concern, with consequences including cognitive decline. Transcranial alternating current stimulation (tACS) holds significant potential for improving cognitive impairment. This study aimed to evaluate the effects of tACS...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

MTAP deficiency in lung cancer cells enhances proliferation and migration and increases vulnerability to bone metastasis

Lung cancer continues to be the leading cause of cancer-related death worldwide. The advent of molecular targeted therapies has significantly changed the treatment landscape. Therefore, identifying new molecular targets is essential for the development of more effective treatment...