Hadassah Medical Center

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Antimalarial exposure and renal histopathologic findings in lupus nephritis

Abstract Objectives This study aimed to evaluate the association between antimalarial exposure and renal histopathologic findings at kidney biopsy in patients with lupus nephritis (LN). Methods This study was conducted within the University of Toronto Lupus Clinic cohort. To ensu...

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-sp...

Adverse childhood experiences and autism spectrum disorder: a retrospective cohort study among late adolescents

Objective To examine the association between Adverse Childhood Experiences (ACEs) and Autism Spectrum Disorder (ASD) identification among Israel Defense Forces (IDF) personnel, focusing on predictors of ASD identification during military service.Methods A retrospective cohort stu...

B‐cell Maturation Antigen ( BCMA )‐ CAR ‐T Therapy in a Patient with Triple Positive Antiphospholipid Syndrome and Recurrent Alveolar Bleeding

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Screening strategies for colorectal cancer: adjusting for individual risk factors

INTRODUCTION: Colorectal cancer (CRC) is a common cause of cancer-related mortality. While overall incidence has declined, certain populations - particularly younger patients - have experienced a rise. This suggests a more complex risk profile than the dichotomous average vs high...

Secondary CNS Lymphoma Masquerading as Recurrent Basal Ganglia Stroke

The basal ganglia comprise a metabolically active group of nuclei implicated in refining movement and emotion. We present the case of a 52-year-old man with common variable immunodeficiency (CVID) who presented to the hospital with severe thrombocytopenia and concern for recurren...

A medically grounded LLM agent–based tool to detect patient safety events in medical records

Large language models (LLMs) have shown incredible promise in medicine. While LLMs may be particularly useful in areas requiring extensive review of clinical records, their use remains limited due to their tendency to hallucinate and fabricate information. Hallucination issues, a...

Factors affecting family consent to corneal donation at a hospital-based eye bank in a tertiary Israeli medical center

Purpose To identify clinical, demographic, and situational factors associated with family consent to corneal donation in a culturally diverse Israeli medical center operating under an opt-in system. Methods This retrospective observational study included 824 deceased individuals...

Adverse Childhood Experiences and New-Onset of PTSD During Military Service.

INTRODUCTION: Exposure to adverse childhood experiences (ACEs) has been increasingly recognized as a potential risk factor for later psychopathology; however, its role in the development of post-traumatic stress disorder (PTSD) during military service remains insufficiently chara...

Preliminary Evidence for the Effects of Bilingual ECoLoGiC Treatment for People With Aphasia

Purpose: The focus of this preliminary study is to report the effects of bilingual Expanding Communication and Language Opportunities Generated in Conversation Treatment (ECoLoGiC-Tx) on formal measures of language, functional communication, and patient/family-reported outcomes (...

Reversing the pipeline: a ‘human-first’ multi-omics approach to cardiovascular discovery

Despite significant biomedical advances, cardiovascular disease remains a leading cause of global mortality. The traditional 'bench-to-bedside' research pipeline, which heavily relies on animal models to guide clinical translation, is often hampered by species-specific physiologi...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Tonabersat Blocks Gap Junctions and Alleviates Thermal Pain Behavior in Mice

Gap junctions (GJs) are channels that enable exchange of ions and small molecules between cells, and have been implicated in the development and maintenance of neuropathic pain. Injury-induced glial activation in sensory ganglia is associated with increased coupling by GJs, which...

Robotic assisted spinopelvic fixation for complex pelvic and spinopelvic fractures: our experience and surgical technique

Complex pelvic and spinopelvic injuries present significant surgical challenges, often requiring intricate reduction and stabilization. Minimally invasive techniques reduce soft-tissue complications but are technically demanding. This study evaluates the safety, feasibility, and...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

An Epstein-Barr virus-encoded snoRNA directs 2′-O-methylation of human rRNAs to control translation and the viral lytic switch

Summary Epstein-Barr virus (EBV) establishes life-long latency in human B-cells yet the molecular strategies that balance its persistence with lytic replication remain incompletely understood. Here, we identify the EBV-encoded small nucleolar RNA, v-snoRNA1, as a bona fide 2′-O-m...

Review of the Ottawa Subarachnoid Hemorrhage Rule

The Ottawa Subarachnoid Hemorrhage (SAH) Rule is a validated clinical decision tool used to identify SAH in patients who present to the emergency department with acute nontraumatic headache. It aims to reduce missed diagnoses while minimizing unnecessary imaging and invasive test...

CT-based radiological score (AMESI CT-score) for severity of bowel injury in acute mesenteric ischemia

PURPOSE: To evaluate whether common bowel-related CT signs alone can reliably identify irreversible bowel injury in acute mesenteric ischemia (AMI) and to develop a radiological score to enhance reporting and assist clinical decision-making. METHODS: This ancillary analysis of th...

Lytic bone lesions in a patient diagnosed with breast cancer – Sarcoidosis

Abstract Sarcoidosis is an inflammatory disease of unknown cause with protean manifestations and presentations which may affect almost any organ. Involvement of intra-thoracic organs (lungs, lymph nodes), reticuloendothelial system, skin, and eyes is predominant. The histological...