Hackensack Meridian Health

A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors

Abstract The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (...

Cyclosporiasis in Pregnancy: A Narrative Review

Objective: Cyclosporiasis, caused by the protozoan parasite Cyclospora cayetanensis, is an emerging foodborne illness of increasing clinical relevance in both endemic and developed countries. Its specific implications during pregnancy remain poorly characterized. Our objective is...

Accuracy of commercial pollen forecasts in the United States

Approximately 80 million Americans suffer from seasonal pollen allergies, and many rely on commercial pollen forecasts to guide exposure reduction and medication timing. However, these forecasts are proprietary, and their accuracy has never been comprehensively evaluated. Here, w...

Comparative Efficacy of Embolic Agents for Single-Session Meningeal Artery Embolization and Surgical Evacuation: Evaluating Liquids, Particles, and Adjunct Coils

BACKGROUND AND OBJECTIVES: Single-session middle meningeal artery embolization (MMAE) combined with surgical evacuation is an emerging strategy for management of patients with chronic subdural hematoma (cSDH). However, comparative outcome data based on embolic material selection...

Rhinolithiasis as a Nidus for Polymicrobial and Anaerobic Colonization: A Case Report

Rhinolithiasis is a rare and underrecognized etiology of chronic sinonasal obstruction and rhinorrhea. The clinical presentation of rhinolithiasis often mimics chronic rhinosinusitis, though often presenting with unilateral symptoms. While most reported cases of rhinolithiasis fo...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Intraoperative Factors Associated With Postoperative Febrile Infectious Complications Following Retrograde Intrarenal Surgery: A Propensity Score-Matched Study

Purpose: To investigate the intraoperative factors associated with postoperative febrile infectious complications following retrograde intrarenal surgery (RIRS).Materials and Methods: A total of 352 patients who underwent RIRS for renal stones between March 2017 and December 2022...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...

Multidisciplinary Approaches to the Management of Spinal Care: A Narrative Review

Abstract For patients with spinal care conditions including degenerative disease, deformity, traumatic injury, and complex pain syndromes, care is frequently fragmented across multiple specialists. This process can delay diagnosis, create complexity in communication, and result i...

Reach of Palliative Care in Parkinson Disease: Progress and Gaps After a National Team-Based Implementation Project.

BACKGROUND AND OBJECTIVES: The value of palliative care (PC) is increasingly recognized in the care of people with Parkinson disease (PWP) and their carepartners. While clinical trials demonstrate PC improves quality of life for PWP and carepartners, little is known about the imp...