Guy's and St Thomas' NHS Foundation Trust

Clinical outcomes of epiretinal membrane surgery in patients with good baseline visual acuity

PURPOSE: For patients with symptomatic epiretinal membrane (ERM), pars plana vitrectomy (PPV) with ERM peel is often performed to improve their distortion. However, there is no clear consensus on visual acuity threshold for performing surgery, nor evidence of potential likelihood...

Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex

Importance Obesity is associated with elevated risks for multiple cancers. How bariatric surgery influences these risks across age and sex is insufficiently understood. Objective To evaluate the association between bariatric surgery and obesity-related cancer (breast, endometrial...

Predicting the clinical course of advanced systemic mastocytosis on treatment with avapritinib or midostaurin

Abstract Advanced systemic mastocytosis (AdvSM) is driven by KIT D816V in approximately 95% of cases. Accurate assessment and prediction of clinical course and disease outcome before and during treatment with the KIT inhibitors midostaurin and avapritinib may facilitate optimizat...

Association between prophylactic hydrocortisone and focal intestinal perforations in preterm infants born before 28 weeks gestation: an observational propensity matched population study in England and Wales

Objective To examine the association between prophylactic hydrocortisone, given to prevent bronchopulmonary dysplasia, and the risk of focal intestinal perforation (FIP) in preterm infants. Design Retrospective cohort study using routinely-collected data from infants born between...

Adults with congenital heart disease: the growing impact of acquired cardiovascular risk factors on late mortality.

BACKGROUND AND AIMS: With improved survival, adults with congenital heart disease (ACHD) increasingly face acquired cardiovascular risk factors; however, their impact on late mortality remains incompletely defined. This study aimed to evaluate the contribution of acquired cardiov...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Congenital heart disease in adults: evolving health systems and lifelong outcomes.

Over the past decades, advances in the diagnosis and treatment of congenital heart disease have reshaped its epidemiology. Congenital heart disease is now increasingly a chronic, lifelong disorder, with adult survivors outnumbering affected children in many countries. This demogr...

Surgical Indications for Type II Thyroplasty in Adductor Spasmodic Dysphonia: A Scoping Review

ABSTRACT Objective This scoping review mapped evidence on surgical eligibility criteria, efficacy, durability, and safety of Type II thyroplasty with titanium bridges for adductor spasmodic dysphonia to identify gaps and inconsistencies among studies and propose preliminary inter...

Protocolised analgosedation in mechanically ventilated adult patients: A scoping review

Purpose Our objectives were to assess structure and content of analgosedation protocols used for mechanically ventilated adult patients, including those receiving extracorporeal membrane oxygenation (ECMO), against current international sedation guidelines, and to explore reporte...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

Validation of a contactless radar system for continuous respiratory rate and heart rate monitoring in clinical and simulated use conditions

Abstract Continuous monitoring of respiratory rate (RR) and heart rate (HR) remains limited in post-acute and long-term care (PALTC) settings, where intermittent spot checks may delay detection of clinical deterioration. Contactless radar-based sensing offers an unobtrusive alter...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

The Power of Data: Assessing Primary Care Performance Using Routinely Collected Emergency Department Data

This paper develops and validates an approach to assess the impact of individual primary care practices (PCPs) on demand for emergency department (ED) services. Using operational data from two geographically adjacent EDs in England, we focus on attendances for ambulatory care-sen...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial

Abstract The NHS-Galleri trial was a randomized controlled trial evaluating a multi-cancer early detection (MCED) test added to usual care. We reported elsewhere that the primary endpoint of a reduction in the incidence of stage III/IV cancer diagnoses in the intervention arm ver...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

The utility of the term ‘Rett‐like’ in relation to Rett syndrome: A systematic review

Abstract Aim To determine clinical features and evaluate the clinical utility of the term ‘Rett‐like’, which is commonly used to describe individuals who do not meet the clinical criteria for a Rett syndrome (RTT) diagnosis, but exhibit some features in keeping with the diagnosis...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...

Diving-related ear, nose, and throat disorders: a structured review using a phase-of-dive framework

Introduction: The aim of this review was to synthesise evidence on ear, nose, and throat (ENT) and related head and neck complications in scuba divers, with emphasis on mechanisms of injury, dive phase-specific risk patterns, and implications for clinical management and fitness-t...

A Prospective Study on the Effect of Coronal Tooth Structure Loss on the Survival of Root Canal‐Retreated Posterior Teeth Restored With Metal Ceramic Crowns With up to 10‐Year Follow‐Up

ABSTRACT Aim The primary aim of this study was to evaluate whether the volume of residual coronal tooth structure influences the survival of root canal‐retreated posterior teeth with up to 10‐year follow‐up. Secondary aims were to assess whether 12‐month radiographic findings and...