Guy's and St Thomas' NHS Foundation Trust

P1.244. Robotic-Assisted Versus Conventional Minimally Invasive Oesophagectomy for Oesophageal Cancer: A Comparative Meta-Analysis of Perioperative and Oncological Outcomes

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Robotic-assisted minimally invasive oesophagectomy (RAMIE) is increasingly adopted to improve surgical precision, mediastinal dissection, and surgeon ergonomics. However, its clinical...

The impact of chemotherapy on frontal lobe executive functioning in adolescents and young adults diagnosed and treated for blood cancers: a systematic review

Abstract Background Cancer-related cognitive impairment (CRCI), often termed “chemobrain,” is a recognised effect of cancer therapy. However, most research has focused on older adults with solid tumours, leaving the neurocognitive consequences of chemotherapy in adolescents and y...

Acute kidney injury and renal replacement therapy: a critical synthesis of metabolic derangements and nutritional implications

Acute kidney injury (AKI) affects up to 50% of critically ill patients and is frequently complicated by severe metabolic derangements, requiring the initiation of replacement therapy (RRT) in 10–15% of cases. Despite substantial progress in the diagnosis of AKI and optimisation o...

Development of an interprofessional education program for aspiration pneumonia care: an action research study

INTRODUCTION/AIM: Aspiration pneumonia has evolved, with demographics shifting to predominantly frail older adults. However, despite the high healthcare impact, there is no established guideline or curriculum for the education and training of healthcare professionals in managing...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...

Sirolimus-eluting balloon for the treatment of peripheral artery disease: SUCCESS PTA real-world single-arm study

BACKGROUND: Outcomes with sirolimus-coated drug-eluting balloons (DEB) have been positive for the treatment of femoropopliteal arterial lesions but have not been studied in a broader patient population. OBJECTIVES: Collect real-world safety and effectiveness data on the SELUTION...

Scalar position characteristics and translocation rates of different lateral wall electrodes within the cochlear basal turn: a cone beam computed tomography study

PURPOSE: This retrospective study systematically compared scalar position characteristics and translocation (STL) rates within the cochlear basal turn (CBT) across three different lateral wall (LW) electrodes. METHODS: The study included 148 morphologically normal cochleae implan...

The Supply chain Health INitiative Evaluation (SHINE) study protocol: evaluating health and wellbeing services delivered through the supply chain

Abstract Background While three-quarters of Small and Medium Sized Enterprises (SMEs) provide some form of health and safety training to their employees, more comprehensive health and wellbeing services (HWS), including health prevention and occupational health activities are not...

Neurodevelopmental and neurological features in children with hypochondroplasia

Abstract Aim To assess neurodevelopmental and neurological features, including neuroimaging abnormalities, in children with molecularly confirmed hypochondroplasia. Method A retrospective cohort study of children with molecularly confirmed hypochondroplasia seen at Evelina London...

Diffusion in deforming semi-permeable media: a Monte Carlo random walk approach

Abstract Diffusion processes in deforming media with semi-permeable barriers are fundamental to understanding many biological and physical systems. The presence of semi-permeable barriers causes temporal and spatial departures from normal diffusion. We present an analytic express...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...

Iron deficiency testing among people with incident heart failure in primary care

Background Given around 50% of people with heart failure have a degree of iron deficiency, guidelines recommend screening. It is uncertain to what extent this is done in primary care and whether testing is equitable. Aim To report the proportion of people with incident heart fail...