Guyra Paraguay

Liquid biopsy in genitourinary cancers: circulating tumor DNA as a predictive biomarker for treatment selection and resistance monitoring

Background: Genitourinary (GU) cancers—prostate, urothelial, and renal cell carcinomas (RCCs)—are a leading source of oncologic morbidity and mortality. Tumor heterogeneity and evolving resistance limit static tissue biopsies, requiring real-time, non-invasive biomarkers. Circula...

Principles or Resources? Best Management of Pediatric Femoral Neck Fractures

Background: Pediatric femoral neck fractures (PFNF) are rare but have a reported complication rate of >30%. To date, there remains a lack of consensus on the definitive risk factors for AVN following PFNF. By comparing the outcomes of PFNF treated at a major US metropolitan area...

YvyrAI: A Spanish-First Recurrent-Deliberation Language Model Architecture with Internal Verification, Conditional Repair, and Adaptive Compute

We present YvyrAI, a Spanish-first decoder-only language model architecture centered on a recurrent module called the DeliberationBlock. A shared Transformer block is iterated within a single forward pass while a learned controller maintains a gated planning state, reads and writ...