Gulbenkian Institute for Molecular Medicine

Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization

Abstract The development of a vaccine capable of conferring sterile protection against Plasmodium , the causative agent of malaria, is a major priority for global eradication efforts. Whole-organism vaccines using liver-infective sporozoites provide high levels of sterile protect...

Stem-cell modeling of cerebellar dysfunction of Angelman syndrome

Angelman syndrome is a severe neurodevelopmental disorder caused by loss of function of the maternal allele of the neuron-specific imprinted gene UBE3A. Although Angelman syndrome presents with developmental delay, ataxia, epilepsy, and speech impairment, the contribution of spec...

Molecular mechanism of complement interference by Streptococcus pyogenes nuclease A

Abstract Bacteria deploy virulence factors to subvert host immunity; yet the molecular details of these interactions often remain limited. Here, we reveal the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterize the structure and dynamic...