Gujarat Technological University

Recent biological evaluations of novel bioactive pyrazole derivatives developed between 2025 and 2026

Pyrazoles represent a privileged heterocyclic scaffold in modern medicinal chemistry owing to their remarkable structural versatility and broad spectrum of biological activities. Over the past decade, pyrazole-containing compounds have gained considerable attention as key pharmac...

Synthesis, Pharmacological Evaluation, Molecular Docking, and In Silico ADMET Profiling of Novel Ibuprofen–Chalcone Hybrids as Potent Anti-Inflammatory Agents

Abstract Objective: Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are severely limited by systemic toxicities. To address these constraints, we designed and synthesized a novel series of ibuprofen–chalcone hybrid molecules, capitalizing on a molecular hybridization s...

A comparative study of turbulence models in a trapezoidal open channel for potential turbine installation site selection

With large-scale projects being installed all over the world, the hydrokinetic (HK) sector has been considered as zero-head power scheme. When site conditions are adequate but ideal velocities are unavailable, choosing an installation location might be challenging. For identifyin...

A review of bias detection and fairness auditing techniques in LLMs

The rise of large language models (LLMs) has sparked worries about inherent social biases and issues related to fairness. Earlier studies have investigated bias identification in word embeddings, interventions aimed at fairness in algorithms, and frameworks for auditing at the sy...

Formulation Strategies for Next-Generation Bispecific Antibodies: Design Considerations and Stability Implications

Bispecific antibodies (BsAbs) represent a transformative class of next-generation biologics, enabling simultaneous binding to two targets and offering mechanisms of action beyond conventional monoclonal antibodies. Their growing clinical success, particularly in T-cell–redirectin...

The design, development of a solar powered adsorption cooling system for Indian conditions

Abstract Adsorption cooling systems have drawn a lot of attention in recent decades because they seem promise in terms of greenhouse gas emissions and ozone layer depletion issues. The system performance is greatly impacted by the operating conditions and the thermos physical cha...

Assessment of drug utilization patterns and associated survival outcomes in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): Insights from a resource-constrained set-up

BackgroundRecurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) has a poor prognosis due to patient rigors, such as malnutrition, uncontrolled comorbidities, age, and performance status. Rapidly evolving treatment paradigms have led to multimodal pharmacothera...

A fuzzy graph-based prediction model for crop yield forecasting under climatic variability

Accurate crop yield prediction under climatic variability is fundamental to food security planning and agricultural policy. Classical statistical and machine learning approaches often struggle to handle imprecise, incomplete, or linguistically described agronomic data arising fro...