Guizhou Provincial People's Hospital

Serial Cross‐Sectional Mapping of Bone Marrow Microenvironment Remodelling During Fracture Repair Using Multiparametric MRI and Histopathology

ABSTRACT Restoring bone marrow microenvironment (BMM) homeostasis is critical for fracture healing, yet non‐invasively tracking physiological events like apoptosis, angiogenesis and matrix remodelling remains challenging. This study evaluated multiparametric 7.0T MRI (T2 mapping...

Cost-Utility Analysis of Comprehensive Integrated Management for Psoriasis and Periodontitis: A Markov Cohort Study

Objectives Psoriasis and periodontitis co-occur in Chinese adults beyond chance expectation, sharing proinflammatory pathways. We modelled the long-term economic value of integrating periodontal care into psoriasis management in China. Methods A nine-state Markov cohort model (1-...

Association between thyroid function profiles and malnutrition severity in elderly patients

Aim To explore the of triiodothyronine (rT3) in the prognostic model of malnutrition in the elderly. Methods A total of 166 elderly patients with malnutrition were included in the experimental group, and 98 healthy people were collected as the control group. The six thyroid funct...

Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induce...

Beyond motor symptoms: associations between sleep disorders and multidomain functional decline in Parkinson’s disease

Sleep disorders are associated with functional outcomes in Parkinson’s disease (PD), yet their multidomain clinical correlates remain incompletely characterized. We analyzed 9195 participants from the National Alzheimer’s Coordinating Center database using inverse probability wei...

Comparing the efficacy of bronchial artery chemoembolization combined with anlotinib versus anlotinib alone in the treatment of advanced non-small cell lung cancer

To compare the clinical effectiveness and safety of addition of anlotinib to bronchial artery chemoembolization (BACE) compared to anlotinib alone in the treatment of stage IIIA-IIIB non-small cell lung cancer (NSCLC) with no mutated driver genes. The clinical data of patients wi...

Ethical tensions in AI-mediated clinical communication: a mixed-methods study of nursing students’ perspectives

The increasing use of artificial intelligence (AI), particularly large language models (LLMs), is reshaping clinical communication by influencing how patients access, interpret, and act upon clinical information. Recent conceptual work has suggested that AI-mediated communication...

G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease

Abstract Whether and how disrupted cholesterol homeostasis contributes to alcohol-related liver disease (ALD) remains elusive. Here, we report that cholesterol biosynthesis is enhanced in ALD livers, driven by a reduction in the H3K9me2 epigenetic landscape orchestrated by the G9...

cGAS–STING signaling in the anterior cingulate cortex modulates electroacupuncture analgesia in a rat neuropathic pain model

Background: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is associated with different neurological dysfunctions in the nervous system. Although electroacupuncture (EA) has been proven to alleviate neuropathic pain (NP), its underlyin...

Continuous Renal Replacement Therapy for Cytokine Storm in Diabetic Kawasaki Shock Syndrome

To report the successful use of continuous renal replacement therapy (CRRT) in a child with type 1 diabetes mellitus (T1DM) and intravenous immunoglobulin (IVIG)-refractory Kawasaki disease shock syndrome (KDSS). A 3-year, 10-month-old boy with poorly controlled T1DM and autoimmu...

Machine learning-based prediction model for 2-year tooth loss risk in periodontitis patients: integrating radiographic features and clinical parameters

To develop and internally–externally validate a multidomain machine-learning (ML) model for 2-year tooth loss in periodontitis patients using exclusively baseline predictors, and to quantify the incremental value of radiographic over clinical features. This multicenter retrospect...

Cellular immune response of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis

BACKGROUND: Available data indicate that people living with HIV (PLWH) have weaker humoral immune responses to COVID-19 vaccines compared to the general population. However, data on cellular immune responses in this group has yet to be established. METHODS: We searched the PubMed...

Cantharidin Causes Hepatotoxicity by Disrupting GSH‐Mediated Redox Homeostasis

ABSTRACT Cantharidin (CTD) possesses potent anticancer activity, whereas its prominent hepatotoxicity severely limits its clinical application. Because the detailed molecular mechanisms responsible for CTD‐triggered hepatotoxicity have not been fully elucidated, additional invest...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

NIR-activated NO-propelled nanomotors for deep tumor penetration and DNA-repair sensitized photothermal therapy of prostate cancer

Photothermal therapy (PTT) for solid prostate cancer (PCa) is often limited by poor intratumoral penetration and rapid DNA repair. Herein, we engineered a PSMA-targeted gas nanomotor that couple deep tumor penetration with DNA repair sensitization for enhanced photothermal/NO the...

Case report and literature review of synchronous follicular and papillary thyroid carcinoma with metastasis to femur

Thyroid carcinoma is common, but the synchronous occurrence of bilateral tumors with discordant histology—specifically follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC)—is extremely rare. It is even more uncommon for such cases to present initially with dis...