Guiyang College of Traditional Chinese Medicine

Serial Cross‐Sectional Mapping of Bone Marrow Microenvironment Remodelling During Fracture Repair Using Multiparametric MRI and Histopathology

ABSTRACT Restoring bone marrow microenvironment (BMM) homeostasis is critical for fracture healing, yet non‐invasively tracking physiological events like apoptosis, angiogenesis and matrix remodelling remains challenging. This study evaluated multiparametric 7.0T MRI (T2 mapping...

Modified Xiaoyaosan Regulates the Neuro-Immune Microenvironment in Chronic Stress: A Preclinical Meta-Analysis and NF-kappaB Pathway Mechanism Exploration

Background: Chronic unpredictable mild stress (CUMS) triggers systemic pathologies, notably depression and endocrine disorders such as hyperprolactinemia (HPRL). Xiaoyaosan (XYS), a classic traditional Chinese medicine formulation, has been proven effective in treating these stre...

Nonmaleficence, noninterference, and fidelity: environmental ethics in Gary Paulsen’s Hatchet (1986)

Abstract In the Anthropocene era, where human activities profoundly alter ecosystems, ethical reflections on human–nature relationships have become increasingly vital. Paul W. Taylor’s environmental ethics—particularly the principles of nonmaleficence, noninterference, and fideli...

Development and validation of a machine learning model for predicting refracture risk in older adults with osteoporotic vertebral compression fractures

Osteoporotic vertebral compression fractures (OVCFs) are common among older adults and are associated with a high risk of subsequent vertebral refracture, which may result in functional decline and reduced quality of life. However, effective tools for identifying Older Adults at...

Identification of Syringic Hydrazide Derivatives as Promising Succinate Dehydrogenase Inhibitors with Superior Antifungal and Anti-Oomycete Efficacy for Ensuring Food Safety

Abstract Fungal diseases remain a major constraint on global crop production, driving the search for fungicides with broader efficacy and improved selectivity. Confronting the dual challenges of structural rigidity and declining antifungal performance in conventional succinate de...

Exploring the treatment of liver cancer with Gehua Hugan Gao based on bioinformatics, network pharmacology, and molecular docking

Gehua Hugan Gao (GHHGG) is a traditional Chinese medicine paste that is chiefly used to treat liver cancer. However, the potential impact of GHHGG on liver cancer remains unclear. We explored how GHHGG treats liver cancer using bioinformatics, network pharmacology, and molecular...

Design and synthesis of 1,2,4-oxadiazole-functionalized funtumine derivatives as potent anticancer agents

A series of innovative 1,2,4-oxadiazole-functionalized funtumine derivatives were designed, synthesized, and assessed for their antiproliferative effects on HCT116, HeLa, and HepG2 human cancer cell lines to discover new natural product-derived anticancer agents. The majority of...

Cantharidin Causes Hepatotoxicity by Disrupting GSH‐Mediated Redox Homeostasis

ABSTRACT Cantharidin (CTD) possesses potent anticancer activity, whereas its prominent hepatotoxicity severely limits its clinical application. Because the detailed molecular mechanisms responsible for CTD‐triggered hepatotoxicity have not been fully elucidated, additional invest...

The relationship between UHR and heart failure: insights from two large database studies

Heart failure (HF) is a major cardiovascular disease that causes high incidence and mortality rates worldwide. The uric acid to high-density lipoprotein ratio (UHR), as an emerging inflammatory and metabolic composite indicator, has recently been considered to be associated with...

Divergent Synthesis of Functionalized Spiroindanediones via CdI2/MgI2-Catalyzed Multiple Cyclocondensation Modes

Abstract Divergent synthesis enables rapid construction of structurally diverse compound libraries from the same universal substrates and is a current research hotspot. Here, the self-(3 + 2), (2 + 1), and (1 + 1 + 1) cyclocondensations of 2-arylidene-1,3-indanediones 1 were real...