Guilan University of Medical Sciences

Interventions addressing moral distress among nurses: A systematic review

BackgroundNurses frequently encounter ethical dilemmas that, when they are unable to act in accordance with perceived ethical standards, may lead to moral distress. Moral distress is associated with a wide range of adverse psychological, physical, and professional outcomes, and i...

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptos...

The Relationship Between Vitamin D Level and Cardiovascular Parameters in Women with Polycystic Ovary Syndrome

Background & Objective: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder among women of reproductive age, often associated with metabolic complications. Vitamin D deficiency is frequently observed in PCOS women and is associated with multiple effects. This study wa...

Prevalence of metabolic syndrome among patients with Alzheimer disease

Background: The relationship between metabolic syndrome (MetS) and Alzheimer disease (AD) has gained increasing attention in recent years, reflecting the growing recognition of metabolic factors in neurodegenerative conditions. The present study aims to estimate the prevalence of...

Three-dimensional CBCT evaluation of maxillary sinus dimensions and volume in relation to sagittal and vertical skeletal patterns: a multivariable analysis

Maxillary sinus morphology is closely related to craniofacial skeletal structures and may influence orthodontic diagnosis and treatment planning, particularly when planning posterior tooth movement and evaluating anatomical limitations of the posterior maxilla. However, the relat...

Educational applications of virtual reality in orthopedic surgery: a scoping review of effectiveness and future directions

Virtual reality (VR) has emerged as a rapidly expanding modality in orthopedic surgical education. However, the evidence regarding its educational value, clinical transferability, and technological consistency remains heterogeneous. This scoping review aims to map the current lan...

Water and Liquid Soap Cleaning of Removable Orthodontic Appliances: A Triple‑Blind Randomized Crossover Study of Microbial Load Reduction

Background: To evaluate the effectiveness of water and a liquid soap solution compared with 0.2% chlorhexidine (CHX) mouthwash in reducing microbial load and microbial plaque formation on removable orthodontic appliances. Methods: Forty-two patients aged 9 to 16 years who had new...

Oral contraceptive and menopausal hormone therapy use and risk of pancreatic cancer: a systematic review, meta-analysis, and dose–response analysis

Pancreatic cancer has a poor prognosis, and hormonal factors have been proposed as potential modifiers of risk. However, the association between exogenous female hormone use and pancreatic cancer remains uncertain. We conducted a comprehensive systematic review and meta-analysis...

The Impact of Telenursing on Patients With Myocardial Infarction Based on a Self-Care Program: A Randomized Clinical Trial.

Background and Aims: Self-care and medication adherence are key factors in the management of patients with myocardial infarction (MI), but many patients face challenges in these areas and require novel care approaches. This study, based on a self-care program, aimed to determine...

Circular RNAs as regulators of epithelial‑mesenchymal transition in gliomas from molecular mechanisms to clinical applications

Epithelial–mesenchymal transition (EMT) is a fundamental biological process that drives glioma invasion, therapeutic resistance, and malignant progression. Recent evidence highlights circular RNAs (circRNAs) as pivotal post-transcriptional regulators that orchestrate EMT through...

Fatal invasive pulmonary aspergillosis caused by Aspergillus texensis: first documented human infection

<title>Abstract</title> Background Invasive Aspergillosis (IA) is a life-threatening infection in immunocompromised patients. Although <italic>Aspergillus fumigatus</italic> predominates, rare and cryptic species are increasingly recognized due to advances in molecular diagnostic...

Expression profiles of long non-coding RNAs ROCR, CFLAR-AS1, ST7-AS1, and ST7-AS2 in diffuse large B-cell lymphoma: a case-control study focusing on GCB and non-GCB subtypes

Abstract Background Diffuse Large B-cell lymphoma (DLBCL) is subdivided into the Germinal Center B-cell (GCB) and non-Germinal Center B-cell (non-GCB)/Activated B-cell (ABC) subtypes, with significant clinical, phenotypic, and genetic variability. Investigating DLBCL’s molecular...

Self-care recovery after ischemic stroke: a quasi-experimental comparison of two psychological interventions

Post-stroke patients often experience cognitive, psychological, and self-care impairments. Comparative evidence on mindfulness-based interventions and cognitive rehabilitation interventions remains limited. This study compared two psychological interventions (Mindfulness-Based St...

Psychometric properties of the Farsi version of the Night Eating Disorder Questionnaire

This study assesses the factor structure and psychometric properties of Farsi version of Night Eating Questionnaire. In this cross-sectional study, we randomly selected 155 people referred to Shafa hospital and private psychiatry clinic in Rasht City, Iran. After translation to F...