Guangzhou Laboratory

Structural basis for loop-dependent inhibition by AcrIIC1 anti-CRISPR proteins

Most characterized anti-CRISPR proteins act via well-defined core inhibitory mechanisms, yet how auxiliary structural elements modulate and potentiate these canonical processes remains poorly understood. Here, we show that AcrIIC1Boe represses Nme1Cas9 activity through an integra...

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

ABSTRACT Successful pregnancy requires dynamic extracellular matrix (ECM) remodeling at the maternal‐fetal interface, yet whether individual collagen subtypes actively regulate this process remains unknown. Here, collagen type XXIV alpha 1 chain (COL24A1), a uterine‐enriched fibr...

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined. Here, we identified Cerebellin‐2‐...

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...