Guangzhou First People's Hospital

Haploidentical hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for severe aplastic anemia patients aged 40–65: a multicenter retrospective study

Abstract Immunosuppressive therapy (IST) plus eltrombopag (EPAG) (IST+EPAG) is the preferred first-line treatment for severe aplastic anemia (SAA) patients over 40 years. However, direct comparison between IST+EPAG and upfront haploidentical hematopoietic stem cell transplantatio...

Tetrandrine-loaded manganese-doped ceria nanozyme for nebulized inhalation therapy of the ROS-driven inflammatory-fibrotic continuum

Pulmonary fibrosis (PF) and acute lung injury (ALI) represent mechanistically interrelated stages along a shared inflammatory-fibrotic disease continuum, both driven by dysregulated macrophage responses and reactive oxygen species (ROS)-mediated signaling. Effective intervention...

Predicting dengue incidence in China using SARIMA and hybrid neural network models: insights for public health planning

Abstract Dengue fever remains a persistent public health challenge in tropical and subtropical regions of China, disproportionately affecting economically disadvantaged and resource-limited areas. Outbreaks of dengue can strain healthcare systems and hinder socio-economic develop...

Effect of Intracameral Air Injection on Corneal Endothelial Cell Loss After Phacoemulsification for Cataracts of LOCS III Nuclear Grade 4 or Higher: A Randomised Clinical Trial

BACKGROUND: To evaluate the effect of intracameral air injection on corneal endothelial cells in patients undergoing phacoemulsification for cataracts with LOCS III nuclear grade 4 or higher. METHODS: A prospective randomised clinical trial. Patients with cataracts of LOCS III nu...

A Biomimetic cascade nanoreactor enabled by tumor microenvironment remodeling for precise CO release and enhanced cu-mediated chemodynamic therapy

Prostate cancer (PCa) is the most prevalent malignant tumor in the male genitourinary system. Carbon monoxide (CO) gas therapy and chemodynamic therapy (CDT) have emerged as alternative treatments for cancer. However, the therapeutic efficacy of both approaches is constrained by...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...

Tumor–host metabolic interactions in the microenvironment and macroenvironment: Mechanisms and targeting strategies

ABSTRACT: Tumor metabolic reprogramming is a hallmark of cancer and is driven not only by intrinsic mechanisms of tumor cells but also by dynamic interactions between the local tumor microenvironment (TME) and the host macroenvironment. This review systematically elaborates on th...

Motor imagery enhances swallowing motor cortex excitability and activates sensorimotor regions: a TMS and fNIRS study

Action observation (AO) and motor imagery (MI) represent promising, non-invasive strategies for promoting neuroplasticity in motor rehabilitation by engaging the shared neural substrates of actual movement. However, their translation to swallowing rehabilitation, particularly for...

Nickase-based suppression of self-ligation in long sticky-end adapters for next-generation sequencing library preparation

The correctness and efficiency of the adapter connection are important factors affecting the quality and yield of the libraries in next-generation sequencing (NGS). Lengthening the sticky ends of the adapters and the targets can effectively improve the efficiency of ligation, how...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

A multi-class gastric biopsy artificial intelligence model developed from whole slide histopathological images

Pathological diagnosis of biopsies remains the gold standard for gastric diseases such as gastric carcinoma (GC), but it suffers from clinical misdiagnosis and high workload. Accurately distinguishing early-stage GC (EGC) from advanced-stage GC (AGC) and preoperatively predicting...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Tumor-targeted nanobubbles delivering PFP/siFGFR1 for US imaging and overcoming enzalutamide-resistant in prostate cancer

Enzalutamide (ENZ) resistance has emerged as a critical therapeutic hurdle in advanced prostate cancer (PCa) management. This study aims to investigate the potential of ultrasound-guided nanobubble-mediated co-delivery of small interfering RNA targeting fibroblast growth factor r...