Guangzhou Chest Hospital

Integrative bioinformatics analysis of Lianmei granules in diabetic nephropathy

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, leading to end-stage renal disease and significant morbidity. Current therapies are limited by efficacy and side effects, highlighting the need for novel treatments. Lianmei granules (LMG) show potential for...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

Spatial distribution, clustering patterns, and economic burden of comorbidities among hospitalised pulmonary tuberculosis patients in Guangdong province: a spatial epidemiological study based on inpatient big data

Background: Comorbidities may complicate the treatment of pulmonary tuberculosis and exacerbate both the clinical and economic burden. We aimed to examine comorbidity patterns, spatial clustering, and economic burden in hospitalised pulmonary tuberculosis (PTB) patients in Guangd...

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide

ABSTRACT Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium with rising global incidence. This pathogen exhibits intrinsic resistance to most antibiotics, presenting a major public health threat. Ethionamide (ETH) requires bioactivation by monooxygenase Et...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...