Guangzhou Chemistry (China)

Integrated inference of cellular compositions and gene expression programs by deconvolution

While computational deconvolution is routinely used to estimate cell-type proportions from tissue mixtures, reconstructing cell-type-specific transcriptomes at single-sample resolution remains a fundamentally underdetermined algorithmic challenge. Consequently, accurate single-sa...

Pathogenesis of lymphangioleiomyomatosis: from TSC mutations, metabolic reprogramming, to microenvironmental interactions

Lymphangioleiomyomatosis is a rare disease primarily affecting women of reproductive age, characterized by progressive pulmonary cystic destruction and driven by TSC gene loss-induced constitutive mTORC1 activation. Current understanding of the disease extends beyond this primary...