Guangzhou Chemistry (China)

Seismic performance and coupling mechanism of modular concrete shear wall structures under multi-directional excitation

To reveal the seismic coupling mechanism of modular integrated construction (MiC) concrete shear wall structures under multi-directional excitation, this paper adopts shaking table test data of a full-scale three-storey typical MiC concrete shear wall unit subjected to unidirecti...

Research on dual coupling model for dynamic analysis of USV-assisted floating pipe docking for TSHDs

Pump-ashore floating pipe docking relies on manual connection for trailing suction hopper dredgers (TSHDs), leading to efficiency and safety bottlenecks. A docking solution involving a cabled unmanned surface vehicle (Cabled-USV) is proposed to address the complexities associated...

Green Synthesis of Functional γ‐Lactams via Metal‐Free Promoted Selective Reductive Amination/Cyclization

Developing a “green” synthetic method to functional γ‐lactam is essential due to their significant importance to numerous fields. In this work, we developed an efficient and highly chemoselective reductive amination/cyclization to access isoindolinones and pyrrolidones from 2‐for...

Dibutyl phthalate disrupts ESR1-GPX4 redox signaling and aggravates ovarian dysfunction in a PCOS-like mouse model

Dibutyl phthalate (DBP), a widely used phthalate plasticizer, has been implicated in reproductive toxicity, but the molecular mechanisms by which experimental DBP exposure affects ovarian granulosa-cell function remain incompletely defined. In an exploratory clinical cohort, urin...

Integrated inference of cellular compositions and gene expression programs by deconvolution

While computational deconvolution is routinely used to estimate cell-type proportions from tissue mixtures, reconstructing cell-type-specific transcriptomes at single-sample resolution remains a fundamentally underdetermined algorithmic challenge. Consequently, accurate single-sa...

Pathogenesis of lymphangioleiomyomatosis: from TSC mutations, metabolic reprogramming, to microenvironmental interactions

Lymphangioleiomyomatosis is a rare disease primarily affecting women of reproductive age, characterized by progressive pulmonary cystic destruction and driven by TSC gene loss-induced constitutive mTORC1 activation. Current understanding of the disease extends beyond this primary...