Guangxi University of Chinese Medicine

Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gastric cancer

Screening for gastric cancer (GC) is critical for improving patient survival, yet current clinical methods suffer from invasiveness and limited sensitivity. The aim of this study is to develop a machine learning model for the non-invasive diagnosis of GC using the whole-genome me...

Association Between Infrared Thermal Characteristics and Clinical Response to Fire Needle Therapy in Knee Osteoarthritis: A Retrospective Study

Objective This study aimed to investigate whether baseline infrared thermography (IRT) features are associated with clinical response to fire needle therapy and evaluate their predictive value for identifying potential responders. Methods A retrospective study included 109 patien...

Screening instruments for somatic symptom disorder: a scoping review of development, validation, and cross-cultural adaptation

Assessment of somatic symptom disorder (SSD) relies on instruments that vary substantially in their target constructs and coverage of DSM-5 diagnostic criteria. This review mapped the DSM-5 content coverage of available instruments and summarized evidence on their psychometric pr...

Clinical features of cough syncope: a systematic review

Abstract Background Cough syncope (CS) is a rare subtype of syncope that remains underrepresented in evidence-based medicine. We aimed to characterize the clinical features of CS, with the aim of improving recognition and optimizing management strategies. Methods We present five...

Research on development strategies for county-level traditional Chinese medicine services based on Grounded Theory

Abstract: This study aims to analyze the development of county-level Traditional Chinese Medicine (TCM) services in Guangxi based on grounded theory, providing theoretical support for proposing corresponding countermeasures to promote the development of TCM services in Guangxi co...

YouTube, TikTok, and Bilibili as sources of medical information on lumbar spinal stenosis

Lumbar spinal stenosis (LSS) is a common degenerative condition that impairs mobility and quality of life, particularly in older adults. Video-sharing platforms are increasingly used for health information, yet the quality and reliability of LSS-related videos and cross-platform...

CAR-based therapies in systemic autoimmunity: from deep immune depletion toward durable immune reset

Systemic autoimmune diseases are sustained by self-renewing networks of autoreactive B cells, antibody-secreting cells, pathogenic T-cell programs and tissue-resident inflammatory niches. Conventional immunosuppression and biologic therapy can reduce disease activity, but often f...

Scoparone protects against acetaminophen-induced acute liver injury: Insights from In vivo experiments and RNA sequencing

Background Scoparone (Sco) is known for its therapeutic effects in alleviating liver injury. This study aims to investigate the protective effects of Sco against acetaminophen-induced acute liver injury (ALI) and explore its underlying mechanisms through in vivo experiments and R...

Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes

Background As a major cause of global mortality, heart failure (HF) has mechanisms that remain elusive. Recent studies suggest β-hydroxybutyrylation (Kbhb) may contribute to its pathogenesis, driving this investigation into Kbhb-associated HF biomarkers. Methods We collected HF-a...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

Vesicular trafficking in immune regulation and disease: from intracellular sorting to intercellular communication

Vesicular trafficking is a fundamental mechanism that maintains cellular homeostasis, enables precise material transport, and regulates signal transduction in eukaryotic cells. In immune cells, vesicular trafficking supports dynamic membrane remodeling and activation-dependent ve...

Volatilomic and transcriptomic analyses uncover the mechanisms underlying flavor-related VOC changes during the harvest period of Citrus reticulata ‘Chachi’

Harvest timing is a critical determinant of the quality of Citrus reticulata ‘Chachi’ (CRC), the sole raw material for Guang Chenpi. However, the molecular mechanisms underlying the dynamics of flavor-related volatile organic compounds (VOCs) across the commercial harvest period...

Potential Ameliorative Effect of Aged Liubao Tea Aqueous Extract on D-Galactose-Induced Pathological Damage in an Alzheimer’s Disease Zebrafish Model

Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder for which effective treatments remain limited. Liubao tea, a distinctive post-fermented dark tea, develops unique aged and areca nut aromas through prolonged storage. However, comprehensive studies on...

Puerarin‐Loaded Macrophage‐Derived Exosomes for Experimental Atherosclerosis

ABSTRACT Atherosclerotic cardiovascular disease (AS) remains a leading global health concern. In this study, we investigated a macrophage‐derived exosome‐based delivery system for puerarin (Pue). The isolated vesicles were characterized by transmission electron microscopy, partic...

Comparative analysis of TP53 gene in Tupaia belangeri subspecies ( Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis ) and identification of mutations in spontaneous tumor cases

The tree shrew (Tupaia belangeri) is an emerging animal model for human diseases, yet the status of the critical tumor suppressor TP53 in its subspecies and spontaneous tumors is unknown. We sequenced the entire TP53 coding region from two subspecies, T. b. yaoshanensis and T. b....

A nomogram for distinguishing ovarian endometrioma in patients with endometriosis: a retrospective study based on clinical indicators

Among the subtypes of endometriosis (EMs), ovarian endometrioma (OE) causes the most direct and progressive damage to ovarian reserve function. This study aimed to identify independent risk factors for OE in patients with EMs, and to develop and validate a clinical classification...

Lycium barbarum Polysaccharides: Extraction, Structural Characteristics, Anti-Inflammatory Mechanisms, Safety Profiles and Applications

Lycium barbarum polysaccharides (LBPs), the primary bioactive components extracted from the traditional medicinal and edible plant Lycium barbarum L., have attracted extensive attention in biomedical research due to their superior anti-inflammatory, immunomodulatory and biologica...

Modification GeneKnockout Diversifies Piericidinsfrom the Marine-Derived Streptomyces psammoticus SCSIO NS126

Abstract Piericidins are α-pyridone agricultural antibiotics produced by actinomycetes. To improve their yield and structural diversity from marine-derived Streptomyces psammoticus SCSIO NS126, this study employed homologous recombination to achieve large-fragment knockout of mod...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

Integrated Transcriptomic Profiling Reveals Candidate Genes for Huperzine A Biosynthesis in Huperzia serrata

Huperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application. This study integrates full-length and...