Guangxi Maternal and Child Health Hospital

Association between hippocampal ferroptosis-related changes and behavioral alterations in CCI rats with neuropathic pain

This study aimed to characterize behavioral alterations induced by chronic constriction injury (CCI) of the sciatic nerve and hippocampal ferroptosis in rats and to explore the association between hippocampal ferroptosis and behavioral changes accompanying neuropathic pain (NP)....

A novel rare missense variant in PLCD1 is associated with recurrent spontaneous abortion and inhibits cell migration and invasion

Recurrent spontaneous abortion (RSA) is a common clinical complication during pregnancy and seriously affects the physical and mental health of women reproductive age. Its etiology and pathogenesis have not yet been fully clarified. In this study, we examined whether genetic vari...

Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation

Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the relationship between circulating S100B levels and OSAHS has not been...

Neural-specific UBAP2L deficiency causes developmental delay and cortical abnormalities in mice

Rare UBAP2L variants have been linked to neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), but the role of UBAP2L in brain development remains unclear. Here, we generated neural-specific conditional knockout mice for Ubap2l using Nestin-Cre system, incl...

Clinical phenotype, family segregation, and follow-up of pediatric distal renal tubular acidosis associated with a homozygous SLC4A1 p.G701D variant

<title>Abstract</title> <bold>Background</bold> We report a case of SLC4A1-related distal renal tubular acidosis (dRTA) in a child with marked skeletal deformities, confirmed by family segregation analysis, and describe the clinical features, genetic findings, and follow-up chang...

A nomogram for distinguishing ovarian endometrioma in patients with endometriosis: a retrospective study based on clinical indicators

Among the subtypes of endometriosis (EMs), ovarian endometrioma (OE) causes the most direct and progressive damage to ovarian reserve function. This study aimed to identify independent risk factors for OE in patients with EMs, and to develop and validate a clinical classification...

Calcium Phosphate Nanoparticle Delivery of siTRIB3 Inhibits EMT and Stemness in NSCLC

Background: TRIB3 is upregulated in non-small cell lung cancer (NSCLC) and associates with worse survival, yet targeted therapeutics remain lacking. Calcium phosphate (CaP) nanoparticles offer biocompatible, serum-stable delivery for siRNA therapy. Here, we developed CaP nanopart...