Guangxi Buffalo Research Institute

Integrated transcriptomic analysis of milk-derived RNA associated with divergent milk yield phenotypes in buffalo

Buffaloes are the second-largest milk-producing animals, and their milk possesses significant nutritional and health benefits. However, the relatively low milk yield severely limited the development of buffalo dairy products. Here, to explore molecular features associated with di...

Lipopolysaccharide-induced glycolytic reprogramming drives H3K18 lactylation-mediated inflammatory injury in buffalo mammary epithelial cells.

reduced lactate accumulation, decreased H3K18la levels, and substantially attenuated inflammatory injury in BuMECs. Together, these findings identify the HK2-lactate-H3K18la axis as a central mechanism in LPS-induced inflammatory injury in BuMECs and underscore its potential as a...