Guangdong Provincial Hospital of Chinese Medicine

Endoscopic Versus Microscopic Decompression for Lumbar Spinal Stenosis: A Structured Debate and International Practice Patterns

Endoscopic spine surgery has advanced from a percutaneous niche technique to a mainstream platform for lumbar decompression. This original study examines the relationship between endoscopic and microscopic platforms across 7 contested domains, using an embedded cross-sectional si...

Ameliorating effects and mechanisms of therapeutic electrical stimulation on the recurrent laryngeal nerve injury model in rats

Recurrent laryngeal nerve (RLN) injury is a rare but serious complication of thyroid surgery and other neck surgery, leading to vocal fold paralysis. The aim of this study was to investigate the therapeutic effects and mechanisms of therapeutic electrical stimulation (TES) on RLN...

Association between dampness syndrome severity and hyperuricemia after accounting for adiposity

Dampness syndrome is a symptom-based traditional Chinese medicine pattern frequently observed in individuals with metabolic disorders. However, whether dampness syndrome severity provides information on hyperuricemia (HUA) beyond conventional adiposity indicators remains unclear....

Metabolomics-driven classification and ratio-based quality control of polygonum multiflorum processing degree using UHPLC-MS/MS

Polygonum multiflorum Thunb. (PM) is a widely used herbal medicine whose efficacy and safety depend critically on the degree of processing; however, current pharmacopeial standards rely on subjective visual inspection, leading to inconsistent product quality. To address this, we...

An exploratory study of peripheral joint deterioration and central sensorimotor network reorganization in people with knee osteoarthritis

Introduction This exploratory study aimed to characterize the differential features and intrinsic associations between peripheral proprioceptive deficits, aberrant quadriceps activation, and central sensorimotor network reorganization in patients with knee osteoarthritis (KOA). M...

Ejiao (Asini Corii Colla) promotes thin endometrium repair via upregulation of the SDF-1/CXCR4 signalling axis in a mouse model

Background Thin endometrium (TE) severely impairs embryo implantation and pregnancy outcomes in reproductive medicine, while first-line oestrogen-based therapy has marked limitations including receptor insensitivity and systemic side effects. Ejiao (Asini Corii Colla), a classic...

PD-1 inhibitor-associated myasthenia gravis with acute myocardial injury: a case report

Abstract Background PD-1 inhibitors can cause serious immune-related adverse events, including myasthenia gravis (MG). The occurrence of myocardial injury during immune checkpoint inhibitor therapy can pose diagnostic challenges. Case presentation A 65-year-old man with hepatocel...

Sulfur dioxide exposure is associated with kidney dysfunction and creatinine abnormalities in Chinese patients with cardiovascular disease or hypertension

This observational study examined the association between long-term ambient air pollution exposure and renal dysfunction among middle-aged and elderly Chinese individuals with hypertension or heart disease. Although previous studies have mainly focused on particulate matter and n...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

Methyl eugenol increases neural microcirculation to promote nerve repair by regulating endothelial cell and Schwann cell communication via Ptn/Sdc4

Neuromicrocirculatory disorders often accompany nerve injury. Improving neural microcirculation can promote the repair of injured nerves. Methyl eugenol is a major bioactive component of Asarum heterotropoides and has been reported to exert analgesic effects in chronic pain. This...

Falciform flap suturing reduces seroma and drain duration in mastectomy±axillary dissection: a retrospective cohort study

Breast cancer represents the most common malignancy among women worldwide, with surgery serving as the primary treatment modality. Postoperative seroma constitutes one of the most frequent complications, with reported incidence rates ranging from 3% to 93% depending on the surgic...

Perioperative prediction of ideal postoperative recovery after kidney transplantation: a multicenter retrospective cohort study

Kidney transplantation is the preferred treatment for end-stage renal disease, but early postoperative outcomes remain heterogeneous. Textbook outcome (TO), a composite measure of an ideal postoperative recovery trajectory, has emerged as a meaningful indicator of surgical qualit...

High tibial osteotomy for proximal tibial osteonecrosis with medial tibial plateau fracture in a patient with prior knee arthroscopy: a case report

High tibial osteotomy (HTO) is a well-established joint-preserving procedure for unloading the medial compartment of the knee. It has been applied in selected cases of spontaneous osteonecrosis or subchondral insufficiency fracture of the knee. However, the coexistence of proxima...

Structural and diffusion MRI markers of the choroid plexus and perivascular regions are associated with Alzheimer’s disease pathology and cognition

Abstract Background Choroid plexus (ChP) morphology and periventricular diffusion alterations have been implicated in Alzheimer’s disease (AD). However, whether ChP volume and the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provide complementar...

Nuciferine Ameliorates Ovariectomy-Induced Bone Loss via TFEB-Mediated Autophagy-Lysosomal Pathway

Background: Postmenopausal osteoporosis is a common metabolic bone disease that leads to reduced bone formation and increased fracture risk. Nuciferine, an aporphine alkaloid from the lotus leaf, can regulate the TFEB-mediated autophagy-lysosomal pathway. This pathway is critical...

A review of power conversion and energy management technologies in rheumatoid arthritis diagnostic equipment

Purpose This study aims to investigate electrical energy management challenges across rheumatoid arthritis (RA) diagnostic devices, addressing a critical gap between large high-resolution imaging equipment and portable microsystems. The research seeks new insights into key power...

Efficacy and safety of Shenfu injection on sepsis-induced myocardial dysfunction: a meta-analysis and trial sequential analysis

The efficacy and safety of Shenfu Injection (SFI) as an adjunctive treatment for sepsis-induced myocardial dysfunction (SIMD) remain uncertain despite preliminary investigations. Eight databases were searched for qualified randomized controlled trials (RCTs) from inception to 10...

Interpretable machine learning model for predicting the ICU readmission of patients after coronary intervention

To develop and validate an interpretable machine learning (ML) model integrated with inflammatory indicators for predicting ICU readmission in patients after coronary intervention (PCI/CABG). We used retrospective data from MIMIC-IV (training, 2196 patients) and MIMIC-III (extern...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Baseline airway dysfunction and small-airway abnormality burden are longitudinally associated with adverse ultradistal radial bone density outcomes in a 5-year cohort

Impaired pulmonary function has been linked to lower bone mineral density and higher fracture risk, but longitudinal evidence on airway dysfunction and subsequent peripheral bone-density outcomes remains limited. We investigated whether baseline airway dysfunction, FEV1/FVC, and...