Guangdong Province Women and Children Hospital

Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays

The high cost and poor portability of external infrared thermal imagers have limited the widespread adoption of photothermal lateral flow immunoassays (PT-LFIAs) in on-site testing. To address this, we developed a smartphone-based handheld Thermal Contrast Amplification (TCA) Rea...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Preconception maternal infection-related exposures and risk of congenital heart disease in offspring: evidence from a large population-based cohort in South China

Abstract Background Maternal infections during pregnancy have been associated with congenital heart disease (CHD) in offspring. However, the associations of preconception maternal infection-related exposures with offspring CHD risk remain unclear. This study aimed to evaluate the...

Long-term fertility preservation and quality-of-life outcomes after high-intensity focused ultrasound ablation versus laparoscopic myomectomy in reproductive-aged women with uterine fibroids: a 5-year propensity-matched cohort study

High-intensity focused ultrasound ablation (HIFU-a) is a novel, non-invasive technique for treating uterine myoma. However, robust evidence comparing long-term multidimensional outcomes—including fertility trajectories, endocrine stability, and quality of life (QoL)—remain contro...

CD9 + B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

ABSTRACT Adenoid hypertrophy (AH) is associated with excessive proliferation of germinal center B (GC‐B) cells, yet the mechanisms underlying GC regression and termination remain poorly understood. This study used single‐cell RNA sequencing (scRNA‐seq) to profile the cellular com...

Prenatal Genetic and Sonographic Features of KBG Syndrome: A Cohort Study of 19 Fetal Cases

ABSTRACT Objective To characterize prenatal sonographic features, genomic findings from chromosomal microarray analysis (CMA) and whole‐exome sequencing (WES), pregnancy outcomes, and postnatal manifestations in KBG syndrome and to provide evidence for prenatal diagnosis and gene...

Associations of early-life exposure to PM2.5 mass and its components with childhood anemia: A cross-sectional study in China, India, and Africa

Childhood anemia remains a major public health concern, but evidence regarding the associations of early-life exposure to PM 2.5 mass and its components with childhood anemia across regions remains limited. We conducted a cross-sectional study of 449,894 children under 5 years fr...

Unraveling the hormonal causality in postpartum depression: findings from a two-sample Mendelian randomization study

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...