Guangdong Institute of Intelligence Science and Technology

The mechanosensitive channel TMEM63B contributes to noxious heat sensation in the dorsal root ganglia

In mammals, heat sensation is primarily mediated by thermosensitive channels, particularly transient receptor potential (TRP) channels, in dorsal root ganglion (DRG) neurons. However, whether additional channels contribute to noxious heat detection remains unclear. Here, we inves...

Inhibition of neuronal DICER–miR-34a/346 signaling attenuates amyloid pathology in 5×FAD mice

MicroRNAs (miRNAs) are critical regulators of genes underlying Alzheimer’s disease (AD) pathogenesis, yet the role of neuronal DICER, a key ribonuclease essential for miRNA maturation, remains unclear. While biochemical analysis of human postmortem cortical tissues revealed upreg...