Guangdong 999 Brain Hospital

Retinoic acid maintains the primordial follicle reserve by inhibiting PI3K/Akt signaling

In female mammals, nonrenewable primordial follicles are orderly activated to maintain reproductive lifespan. However, the initiating regulator(s) of primordial follicle maintenance and activation remain poorly characterized. RA synthesis enzymes were mainly expressed in the pre-...

Structural and diffusion MRI markers of the choroid plexus and perivascular regions are associated with Alzheimer’s disease pathology and cognition

Abstract Background Choroid plexus (ChP) morphology and periventricular diffusion alterations have been implicated in Alzheimer’s disease (AD). However, whether ChP volume and the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provide complementar...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

A Wearable Multimodal Assistive Interface for Virtual Cursor Control in Stroke Survivors with Upper-Limb Impairment

Stroke survivors with upper-limb impairments often have difficulty using conventional computer interfaces, which limits their ability to perform daily computer-related activities independently. This study developed a wearable multimodal assistive interface that enables computer i...

Resveratrol reprograms ARG1⁺ microglia to remodel the immunosuppressive microenvironment in primary CNS lymphoma via secretion cytokine

Abstract Primary central nervous system lymphoma (PCNSL) is a CNS-restricted lymphoma with poor prognosis. Despite sharing pathological features with systemic diffuse large B-cell lymphoma (DLBCL), PCNSL exhibits unique molecular mutation patterns, highlighting the critical role...