Guang’anmen Hospital

A Hippo-YAP pathway activity-guided multimodal framework highlights NDRG1-associated tumor microenvironmental features in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is characterized by marked molecular and histopathological heterogeneity, which limits the performance of conventional clinicopathological risk stratification systems. Hippo-YAP signaling is closely involved in HCC progression and tumor microenviron...

Endothelial Bmal1 coordinates intrinsic and paracrine mechanisms to limit post-injury vascular restenosis

Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated neointimal hyperplasia and delayed endothelial repair. Bmal1, a core component of the molecular clock, plays a criti...